Phosphoramidates for the treatment of hepatitis B virus

A compound having the formula:

• or a pharmaceutically acceptable salt thereof, wherein
• each R1 is, independently, selected from one of the formula:
• Y is O or S;
• Y1 is OH, OAryl, OAlkyl, or BH3−M+;
• Y2 is OH or BH3−M+;
• Aryl is aromatic or heteroaromatic;
• R3 is hydrogen, deuterium, fluoromethyl, difluoromethyl, trifluoromethyl, alkyl, alkenyl, alkynyl, amino, fluoro, chloro, bromo, iodo, hydroxyl, cyano, formyl, acyl, substituted amino, or hydroxymethyl;
• R4 is alkyl, branched alkyl, cycloalkyl, or lipid;
• R5 is hydrogen, deuterium, hydroxyl, cyano, azido, amino, substituted amino, aryl, heteroaryl, substituted aryl, lipid, C1-22 alkoxy, C1-22 alkyl, C2-22 alkenyl, C2-22 alkynyl, or substituted heteroaryl;
• and
• R6 is methyl, ethyl, tert-butyl, C1-22 alkoxy, C1-22 alkyl, branched alkyl, cycloalkyl, aryl, substituted aryl, or alkyoxy.