Biaryl amides with modified sugar groups for treatment of diseases associated with heat shock protein pathway
AssigneeReata Pharmaceuticals, Inc.
InventorsXin Jiang, Melean Visnick, Christopher F. Bender, Gary Bolton, Bradley Caprathe, Chitase Lee
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Abstract
Provided herein are biaryl amides and coumarin-based compounds with modified sugar groups having the formulas: wherein variables are as defined herein. Pharmaceutical compositions of the compounds are also provided. These biaryl amides and coumarin-based derivatives with modified sugar groups are useful for treatment and prevention of diseases and disorders, including neurological disorders, such as neurodegenerative diseases and nerve damaging disorders, for example, diabetic peripheral neuropathy.
Claims14
A method of treating diabetic peripheral neuropathy, in a patient in need thereof comprising administering to the patient in need thereof a therapeutically effective amount of a compound of the formula:
- wherein:
- n is 1;
- Y1 is -alkanediyl(C≤6)-, —C(O)-alkanediyl(C≤6)-, or a substituted version of any of these groups;
- Y2 is O;
- R3 is —NR11R11′ or —C(O)NR12R12′, wherein:
- R11 and R11′ are each independently hydrogen, alkyl(C≤6), substituted alkyl(C≤6), acyl(C≤6), or substituted acyl(C≤6);
- R12 and R12′ are each independently hydrogen, alkyl(C≤6), or substituted alkyl(C≤6);
- R7 is alkyl(C≤6) or a substituted alkyl(C≤6);
- R8 is hydroxy, alkoxy(C≤6), or substituted alkoxy(C≤6);
- and
- R9 and R10 are each hydroxy;
- or a pharmaceutically acceptable salt of the formula.
Dependencies are inferred from the claim text.