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US 12,595,269 B2Granted
Morpholine-like monoamine releasers
AssigneeSolvonis Therapeutics Ireland Holdings Limited
InventorsAlan Borthwick, Fabrizio Micheli, Alessandra Micoli, Ferruccio Palazzesi, Agostino Cianciulli, Robin Tyacke, David Nutt
Life of this patent
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Abstract
Disclosed herein are certain therapeutic substituted heterocyclic bridged ring compounds, including substituted morpholine, thiomorpholine, and piperidine compounds and their homologues, having various advantages over current compounds used in certain methods of drug-assisted therapy, such as MDMA, together with pharmaceutical compositions containing such compounds, and methods of their use to treat mental health disorders and CNS disorders.
Claims20
A compound having the structure of Formula (2):
- or a pharmaceutically acceptable salt, hydrate, or solvate thereof, wherein:
- R1, R2, and R3 are each independently hydrogen, —CH3, —OCH3, —CF3, or halogen;
- or
- two of R1, R2 and R3 are combined with the atoms to which they are each attached to form a C1-8 cycloalkyl, C1-10 heterocycloalkyl, or C6-12 aryl;
- X is O, S, —O—CH2—, —O—C(O)—, or —S—CH2—;
- y is 1 or 2;
- and
- wherein at least one of R1, R2, and R3 is not hydrogen.
5 more elements
Dependencies are inferred from the claim text.