# US 12,595,258 B2 · Heterocyclic derivatives, pharmaceutical compositions and their use in the treatment or amelioration of cancer

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- Number: US 12,595,258 B2
- Document ID: US12595258B2
- Status: Granted
- Kind: B2
- Application number: 19/179,235
- Filed: 2025-04-15
- Published: 2025-07-31
- Granted: 2026-04-07
- Earliest claimed: 2025-04-15
- Assignees: Tolremo Therapeutics AG
- Applicants: Tolremo Therapeutics AG
- Inventors: Charles-Henry Fabritius; Koen Hekking; Dorothea Gruber; Rutger Folmer; Stefanie Flückiger-Mangual; Thomas Bohnacker; Martin Schwill; Debora Schmitz-Rohmer
- Web page: https://patentgrep.com/patent/US12595258B2

## CPC

- C07D 401/04: directly linked by a ring-member-to-ring-member bond
- C07D 413/14: containing three or more hetero rings
- A61K 31/506: not condensed and containing further heterocyclic rings
- A61P 35/00: Antineoplastic agents
- C07D 401/14: containing three or more hetero rings
- C07D 405/14: containing three or more hetero rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to compounds of formula (I) or salts, solvates, cocrystals, tautomers, or mixtures thereof. Furthermore, the present invention relates to pharmaceutical compositions comprising said compounds. Moreover, the present invention relates to the compounds of formula (I) or the salts, solvates, cocrystals, tautomers, or mixtures thereof or the pharmaceutical compositions for use as a medicament and to the compounds of formula (I) or the salts, solvates, cocrystals, tautomers, or mixtures thereof or the pharmaceutical compositions for use in the treatment or amelioration of cancer. Optionally, the compounds of formula (I) or the salts, solvates, cocrystals, tautomers, or mixtures thereof or the pharmaceutical compositions are administered in combination with a second therapeutic agent, in particular an anti-cancer agent.

## Claims

### Claim 1

A compound having the following formula:
or a pharmaceutically acceptable salt, solvate, cocrystal tautomer, or a mixture thereof.

### Claim 2 (depends on 1)

A pharmaceutical composition comprising a pharmaceutically effective amount of the compound according to claim 1 or a pharmaceutically acceptable salt, solvate, cocrystal, tautomer or a mixture thereof, and a pharmaceutically acceptable carrier, diluent or excipient.

### Claim 3

A compound having the following formula:

### Claim 4 (depends on 3)

A pharmaceutical composition comprising a pharmaceutically effective amount of the compound according to claim 3 and a pharmaceutically acceptable carrier, diluent or excipient.