Amidines and amidine analogs for the treatment of bacterial infections and potentiation antibiotics

A compound of Formula V:

• or a pharmaceutically acceptable salt thereof;
• wherein:
• R1 is independently selected at each occurrence from halogen, hydroxyl, C1-C6alkoxy, C1-C6haloalkoxy, C2-C6alkanoyl, cyano, azido, nitro, —COOH, —CONH2, —P(O)(OH)2, —N(R5)(R5′), —S(O)R5, —SO2R5, —SO3R5, —SO2N(R5)(R5′), —OSO2R5, —N(R5′)SO2R5, C1-C6alkyl, C3-C6cycloalkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6haloalkyl, C1-C6aliphatic, thiol, C1-C6alkylthiol, and (C1-C6haloalkyl)thiol;
• Z1 and Z2 are independently selected from O, S, N(R5), and C═O;
• R2 and R2′ are independently selected at each occurrence from hydrogen, C1-C6alkyl, C3-C6cycloalkyl, C1-C6haloalkyl, and C1-C6aliphatic;
• R5 and R5′ are independently selected at each occurrence from hydrogen, C1-C6alkyl, C3-C6cycloalkyl, C1-C6haloalkyl, and C1-C6aliphatic;
• RA and RB are independently selected from hydrogen and C1-C6alkyl;
• R6 and R7 is independently selected at each occurrence from hydrogen, halogen, hydroxyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkanoyl, cyano, azido, nitro, —COOH, —CONH2, —P(O)(OH)2, —N(R5)(R5′), —S(O)R5, —SO2R5, —SO3R5, —SO2N(R5)(R5′), —OSO2R5, —N(R5′)SO2R5, C1-C6alkyl, C3-C6cycloalkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6haloalkyl, C1-C6aliphatic, thiol, C1-C6alkylthiol, and (C1-C6haloalkyl)thiol;
• m and n are independently selected from 1, 2, 3, and 4;
• p and r are independently selected from 1, 2, 3, and 4;
• and
• q is 0, 1, 2, 3, or 4;
• wherein if q is 0, then at least one of R6 and R7 is not hydrogen.