Bioactive benzocycloheptene analogues from himachalenes and its applications

A compound of formula (I), (II), (III), (IV), (V), or (VI):

• or a pharmaceutical acceptable salt or enantiomer thereof, wherein, in each of formulas (I), (II), (III), (IV), (V), and (VI):
• Y is selected from the group consisting of carbon, nitrogen, oxygen, and sulfur;
• Z is selected from the group consisting of —H, C1-C6 alkyl, C1-C6 aryl, halogen, oxygen, nitrogen, and sulfur;
• R1 is selected from the group consisting of —H, —OH, N-substituted benzylamine, N- substituted aniline, S-substituted thiophenes, carboxylic acids, and halogen;
• R2 is selected from the group consisting of —H, C1-C6 alkyl, C1-C6 aryl, halogen, C1-C6 amine, and C1-C6 carbonyl groups;
• R3 is selected from the group consisting of —H, C1-C6 alkyl, C1-C6 aryl, and thiophenes;
• X is selected from the group consisting of carbon, nitrogen, oxygen, and sulfur;
• R4 is selected from the group consisting of —H, C1-C6 alkyl, C1-C6 aryl, halogen, and aldehyde-substituted benzenesulfonamides;
• R5 is selected from the group consisting of —H, C1-C6 alkyl, C1-C6 aryl, halogen, and C1-C6 carbonyl group;
• and
• R6 is selected from the group consisting of —H, C1-C6 alkyl, C1-C6 aryl, and C1-C6 amine group.