Substituted 6,7-dihydro-5H-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof

A compound of the formula (I) or a pharmaceutically acceptable salt thereof:

• wherein:
• R1 and R2 independently represent a hydrogen atom or a deuterium atom;
• R3 represents a hydrogen atom, a —COOH group or a —OH group;
• R3′ and R3″ independently represent a hydrogen atom, a methyl group, a methoxy group, a chlorine atom, a fluorine atom, or a cyano group;
• R4 and R5 independently represent a hydrogen atom, a fluorine atom, a —NH2 group, a (C1-C3)alkyl group, a (C1-C3)alkoxy group, or a —OH group;
• or R4 and R5 together form an oxo group or R4 and R5 together form a ═NOCH3 group or a (C3-C5)cycloalkyl group with the carbon atom to which they are attached;
• R7 represents a hydrogen atom, a methyl group, a —OH group or a fluorine atom;
• or alternatively R4 and R7 together form a cyclopropyl group together with the bond to which they are attached such that, with the adjacent azetidine group, results in an azaspiro[2.3]hexane;
• R6 represents a group selected from:
• a phenyl group, said phenyl group being optionally substituted by 1 to 3 substituents independently selected from a halogen atom;
• a (C1-C6)alkyl group optionally substituted with a cyano group or a —OH group;
• a (C1-C6)fluoroalkyl group;
• a (C3-C6)cycloalkyl group;
• a (C1-C6)alkoxy group;
• a (C1-C6)fluoroalkoxy group;
• a cyano group;
• a trifluoromethylsulfonyl group;
• a (C1-C4)alkylthio group;
• a (C1-C4)fluoroalkylthio group;
• a (C1-C4)alkylsulfonyl group;
• and a —OH group;
• a fused phenyl group, selected from phenyl groups fused with a (C3-C6)cycloalkyl, wherein the (C3-C6)cycloalkyl ring optionally comprises an unsaturation and, wherein the fused phenyl is optionally substituted with 1 to 3 substituents independently selected from a (C1-C3)alkyl group, a hydroxy group, a halogen atom, a (C1-C6)fluoroalkyl group and a (C1-C3)alkoxy group;
• a bicyclic group comprising 5 to 12 carbon atoms, optionally comprising 1 to 2 double bonds and optionally substituted with 1 to 4 substituents independently selected from:
• a fluorine atom, a —OH group, a (C1-C3)-alkyl group, a (C1-C3)fluoroalkyl group, a (C1-C3)alkoxy group, a (C1-C3)fluoroalkoxy group and an oxo group;
• a heteroaryl group comprising 2 to 9 carbon atoms and comprising from 1 to 3 heteroatoms independently selected from oxygen, nitrogen and sulfur, and at least 5 atoms including carbon atoms and heteroatoms, said heteroaryl group being optionally substituted with 1 to 3 substituents independently selected from a halogen atom, a (C1-C6)alkyl group, a (C1-C6)fluoroalkyl group, a (C1-C6)alkoxy group, a (C1-C6)fluoroalkoxy group, a cyano group, a carbamoyl group and a —OH group;
• a cycloalkyl group comprising 3 to 7 carbon atoms, said cycloalkyl group being saturated or partially saturated and being optionally substituted with 1 to 4 substituents independently selected from:
• a fluorine atom, a —OH group, a (C1-C3)alkyl group, a (C1-C3)fluoroalkyl group, a (C1-C3)alkoxy group, a (C1-C3)fluoroalkoxy group, an oxo group,
• a (C3-C6)cycloalkyl group, and a phenyl group, said (C3-C6)cycloalkyl or phenyl groups being optionally substituted with one or two halogen atom(s) or (C1-C3)alkyl group(s);
• a (C3-C6)cycloalkyl(C1-C3)alkyl group, optionally substituted on the cycloalkyl with 1 to 4 substituents independently selected from:
• a fluorine atom, a —OH group, a (C1-C4)alkyl group, a (C1-C3)fluoroalkyl group, a (C1-C3)fluoroalkoxy group and an oxo group;
• a 3 to 8 membered-heterocycloalkyl group comprising 1 or 2 heteroatoms independently selected from oxygen, nitrogen and sulfur, said heterocycloalkyl group being saturated or partially saturated and being optionally substituted with 1 to 3 substituents independently selected from:
• a fluorine atom, a (C1-C3)alkyl group, a (C1-C3)fluoroalkyl group, a (C1-C3)fluoroalkoxy group, an oxo group, a (C1-C3)alkoxy group and a —OH group;
• a (C1-C6)alkyl group, said alkyl group being optionally substituted with 1 to 4 substituents independently selected from:
• a fluorine atom, a (C1-C3)alkoxy group, a (C1-C3)fluoroalkoxy group and a —OH group;
• and
• a phenyl(C1-C2)alkyl group, said phenyl group being optionally substituted with 1 to 3 substituents independently selected from a halogen atom;
• a (C1-C3)alkyl group;
• a (C1-C3)fluoroalkyl group;
• a (C1-C3)alkoxy group;
• a (C1-C3)fluoroalkoxy group;
• a cyano group;
• and a —OH group;
• X represents —CH2—, —O— or —S—;
• Y represents —CH═, —N═ or —CR″═, wherein R″ represents a (C1-C3)alkyl group or a halogen atom, a cyano group, or a (C1-C3)fluoroalkyl group;
• R8 independently represents a (C1-C3)alkyl group, a halogen atom, a cyano group, or a (C1-C3)fluoroalkyl group;
• R9 represents a hydrogen atom or a fluorine atom;
• R10 and R10′ independently represent a hydrogen atom or a fluorine atom;
• R11 represents a hydrogen atom, a (C1-C3)alkyl group or a cyclopropyl;
• n is 0, 1 or 2, and
• m is 0 or 1.