Continuos flow synthesis of cannabidiol
AssigneeIndena S.p.A.
InventorsAlessandro Palmieri, Roberto Ballini, Pietro Allegrini, Daniele Ciceri
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Abstract
A process for the synthesis of Cannabidiol of formula (1): (1) is herein disclosed. The process comprises contacting a solution [solution (S1)] of (+)-p-mentha-diene-3-ol of formula (4) (4) or an ester thereof and olivetol of formula (3): (3) with a solution [solution (S2)] of a non-supported Lewis acid in a continuous flow reactor and treatment of the resulting mixture with a basic solution. The process offers the advantage that it can be conveniently carried out on an industrial scale while avoiding the formation of abnormal CBD and THC (Δ9-tetrahydrocannabinol).
Claims12
A process for the synthesis of Cannabidiol of formula (1):
- said process comprising the following steps:
- a) contacting a solution [solution (S1)] of (+)-p-mentha-diene-3-ol of formula (4)
- or an ester thereof and olivetol of formula (3):
- and a solution [solution (S2)] of a non-supported Lewis acid in an organic solvent, wherein said non-supported Lewis acid is BF3-Et2O, in a continuous flow reactor to obtain a first mixture [mixture (M1)] comprising Cannabidiol;
- and
- b) contacting mixture (M1) with a basic solution [solution (S3)] to obtain a second mixture [mixture (M2)]
- c) separating Cannabidiol from mixture (M2),
- wherein residence time in the continuous flow reactor of step a) is between 1 to 10 minutes and wherein Cannabidiol is obtained with a molar yield of 34% and no formation of tetrahydrocannabinol.
Dependencies are inferred from the claim text.