Combined radiation acoustics and ultrasound for radiotherapy guidance and cancer targeting

A method for adapted radiotherapy comprising:

• receiving, at transducers, signals from a region of interest, the received signals comprising ionizing radiation acoustic signals and ultrasound signals, the ionizing radiation acoustic signals and the ultrasound signals being generated in response to radiation applied to the region of interest;
• processing the received signals and determining relative dosimetry imaging of the radiation applied to the region of interest;
• determining spatial imaging of tissue in the region of interest;
• determining a property of tissue structures in the region of interest;
• deriving absolute dosimetry imaging from the relative dosimetry imaging, spatial mapping, and property of tissue structures in the region of interest;
• fusing the absolute dosimetry imaging and the spatial imaging of the tissue;
• and
• providing feedback to a radiation source and updating parameters for a next radiation dosage.