Systems and methods for simulating cardiovascular fluid flow

A method for simulating a target fluid flow profile in test member when a perfusion system is connected to the test member to create a fluid circuit therewith, the method being executed by a processor communicatively coupled to:

• a first valve in an input channel of the perfusion system, the input channel configured to supply fluid to the test member when connected thereto, and
• a second valve in an output channel of the perfusion system, the output channel configured to receive fluid from the test member when connected thereto,
• the method comprising:
• obtaining input, by the processor, of the target fluid flow profile, the target fluid flow profile comprising a target pulsatile flow component and a target systemic resistance component;
• controlling, by the processor, the first valve based on a preliminary first valve parameter, and obtaining input from a sensor of a measured fluid flow parameter in the input channel;
• adjusting the preliminary first valve parameter until the measured fluid flow parameter corresponds to the target pulsatile flow component;
• controlling the second valve based on a second preliminary second valve parameter, and obtaining input from a sensor of a measured fluid flow parameter;
• and
• adjusting the second preliminary second valve parameter until the measured fluid flow parameter corresponds to the target systemic resistance component.