# US 12,594,407 B2 · Preparation delivery assembly and device having multiple needles > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,594,407 B2 - Document ID: US12594407B2 - Status: Granted - Kind: B2 - Application number: 17/807,224 - Filed: 2022-06-16 - Published: 2022-09-29 - Granted: 2026-04-07 - Earliest claimed: 2019-08-22 - Assignees: Beijing BOE Technology Development Co., Ltd.; Boe Technology Group Co., Ltd. - Applicants: Beijing Boe Technology Development Co., Ltd.; Boe Technology Group Co., Ltd. - Inventors: Yongchun Lu; Hui Li; Pan Li; Chunping Long - Web page: https://patentgrep.com/patent/US12594407B2 ## CPC - A61M 37/0015: {by using microneedles} - G03F 7/0035: {Multiple processes, e.g. applying a further resist layer on an already in a previously step, processed pattern or textured surface} - A61M 2037/0023: {Drug applicators using microneedles} - A61M 2037/003: {having a lumen} - A61M 2037/0053: {Methods for producing microneedles} - A61M 2205/3368: Temperature - A61M 2205/3606: cooled - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - G03F: PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR; (phototypographic composing devices B41B; photosensitive materials or processes for photographic purposes G03C; electrophotography, sensitive layers or processes therefor G03G) ## Abstract A preparation delivery assembly includes: a first substrate, a second substrate, and at least two needles of different lengths. Two side walls are provided between the first and second substrates to define a first chamber. At least one first channel that is in communication with the first chamber is provided in the second substrate in a direction perpendicular to the second substrate. And the needles are arranged on a surface of the second substrate, and each needle is in communication with the first chamber to deliver the preparation. A third channel is provided in the first substrate in a direction perpendicular to the first substrate, and one end of the third channel is in communication with the first chamber so as to guide the preparation introduced from the other end of the third channel into the first chamber. ## Claims ### Claim 1 A preparation delivery assembly, comprising: a first substrate, a second substrate, and at least two needles of different lengths, each of the needles is a hollow needle having a hollow structure; wherein two side walls are provided between the first substrate and the second substrate to define a first chamber for containing a preparation by the first substrate, the second substrate, and the two side walls; at least one first channel that is in communication with the first chamber is provided in the second substrate in a direction substantially perpendicular to the second substrate; and the needles are arranged on a surface of the second substrate distal to the first substrate, and each of the needles is in communication with the first chamber through the at least one first channel to deliver the preparation, wherein a third channel is provided in the first substrate in a direction substantially perpendicular to the first substrate, and one end of the third channel is in communication with the first chamber so as to guide the preparation introduced from the other end of the third channel into the first chamber; wherein at least one of the first and second substrates is made of a flexible material; wherein at least one recess is provided on a surface of the first substrate proximal to the second substrate, and an elastic isolation membrane is provided between the recess and the first chamber to define a second chamber by the recess and the elastic isolation membrane; and a second channel is further provided in the first substrate in a direction substantially parallel to the first substrate, and one end of the second channel is in communication with the second chamber, and the other end of the second channel is in communication with outside so as to introduce air from the outside into the second chamber; wherein when external pressure is applied to the assembly, a valve at the other end of the second channel is opened to introduce air into the second chamber, and the air in the second chamber pushes up the elastic isolation membrane, so that the preparation flows towards the first channel. ### Claim 2 (depends on 1) The assembly according to claim 1, wherein the at least one first channel comprises a plurality of sub-channels, each of the sub-channels corresponds to one length of needle among the at least two needles of different lengths; wherein one end of each of the plurality of sub-channels is interconnected within the second substrate and extends to a surface of the second substrate facing the first substrate, and the other end of each of the plurality of sub-channels extends to the corresponding needle respectively. ### Claim 3 (depends on 1) The assembly according to claim 1, further comprising: a temperature control circuit configured to sense a temperature of the preparation contained in the first chamber, and adjust the temperature of the preparation when it is outside an allowable range. ### Claim 4 (depends on 1) The assembly according to claim 1, wherein the number of the recesses is greater than one. ### Claim 5 (depends on 1) The assembly according to claim 1, wherein an inner wall of the needles and the surface of the second substrate distal to the first substrate are substantially perpendicular to each other. ### Claim 6 (depends on 5) The assembly according to claim 5, wherein hydrophilicity and hydrophobicity of the inner wall of the needles match those of the preparation. ### Claim 7 (depends on 1) The assembly according to claim 1, wherein the needles of different lengths have different inner diameters. ### Claim 8 (depends on 1) The assembly according to claim 1, wherein inner diameters of the needles are in a range of 10 micrometers to 80 micrometers. ### Claim 9 (depends on 1) The assembly according to claim 1, wherein distances between the respective needles range from 100 micrometers to 500 micrometers. ### Claim 10 (depends on 1) The assembly according to claim 1, wherein the lengths of the needles are in a range of 25 micrometers to 1000 micrometers. ### Claim 11 (depends on 1) The assembly according to claim 1, wherein a lateral side of a cross section of the needles taken in a direction perpendicular to the surface of the first or second substrate has an inclination angle of 10 degrees to 25 degrees with respect to a normal direction of the surface of the first or second substrate. ### Claim 12 A preparation delivery device, comprising a preparation delivery assembly, and a storage portion for storing a preparation, the storage portion is in communication with the preparation delivery assembly to supply the preparation to the preparation delivery assembly, wherein the preparation delivery assembly comprises: a first substrate, a second substrate, and at least two needles of different lengths, each of the needles is a hollow needle having a hollow structure; wherein two side walls are provided between the first substrate and the second substrate to define a first chamber for containing a preparation by the first substrate, the second substrate, and the two side walls; at least one first channel that is in communication with the first chamber is provided in the second substrate in a direction substantially perpendicular to the second substrate; and the needles are arranged on a surface of the second substrate distal to the first substrate, and each of the needles is in communication with the first chamber through the at least one first channel to deliver the preparation, wherein a third channel is provided in the first substrate in a direction substantially perpendicular to the first substrate, and one end of the third channel is in communication with the first chamber so as to guide the preparation introduced from the other end of the third channel into the first chamber; wherein at least one of the first and second substrates is made of a flexible material; wherein at least one recess is provided on a surface of the first substrate proximal to the second substrate, and an elastic isolation membrane is provided between the recess and the first chamber to define a second chamber by the recess and the elastic isolation membrane; and a second channel is further provided in the first substrate in a direction substantially parallel to the first substrate, and one end of the second channel is in communication with the second chamber, and the other end of the second channel is in communication with outside so as to introduce air from the outside into the second chamber; wherein when external pressure is applied to the assembly, a valve at the other end of the second channel is opened to introduce air into the second chamber, and the air in the second chamber pushes up the elastic isolation membrane, so that the preparation flows towards the first channel. ### Claim 13 (depends on 12) The device according to claim 12, wherein the at least one first channel comprises a plurality of sub-channels, each of the sub-channels corresponds to one length of needle among the at least two needles of different lengths; wherein one end of each of the plurality of sub-channels is interconnected within the second substrate and extends to a surface of the second substrate facing the first substrate, and the other end of each of the plurality of sub-channels extends to the corresponding needle respectively. ### Claim 14 (depends on 12) The device according to claim 12, wherein the preparation delivery assembly further comprises: a temperature control circuit configured to sense a temperature of the preparation contained in the first chamber, and adjust the temperature of the preparation when it is outside an allowable range. ### Claim 15 (depends on 12) The device according to claim 12, wherein the number of the recesses is greater than one.