# US 12,594,359 B2 · Antimicrobial bone cement > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,594,359 B2 - Document ID: US12594359B2 - Status: Granted - Kind: B2 - Application number: 18/335,973 - Filed: 2023-06-15 - Published: 2024-05-16 - Granted: 2026-04-07 - Earliest claimed: 2022-06-16 - Applicants: Cyrus Talebpour; Houshang Darvishi Alamdari; Hossein Salimnia; Rahul Vaidya - Inventors: Cyrus Talebpour; Houshang Darvishi Alamdari; Hossein Salimnia; Rahul Vaidya - Web page: https://patentgrep.com/patent/US12594359B2 ## CPC - A61L 24/0015: {Medicaments; Biocides} - A61L 24/06: obtained by reactions only involving carbon-to-carbon unsaturated bonds {(A61L24/043, A61L24/046 take precedence)} - A61L 2300/102: Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates - A61L 2300/104: Silver, e.g. silver sulfadiazine - A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents - A61L 2400/12: Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces - A61L 2430/02: for reconstruction of bones; weight-bearing implants - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) ## Abstract The subject matter of the present invention is incorporating nanostructured antimicrobial silver perovskite particles into bone cement made of Poly Methyl Methacrylate (PMMA). This is accomplished by mixing the nanostructured antimicrobial particles with the cement powder prior to the addition of liquid monomer. The spontaneous and dispersion of the antimicrobial particles in the cement during preparation allows using a small weight for weight ratio of antimicrobial particles relative to the total mass of the cement, thereby substantially preserving the antimicrobial cement's biocompatibility compared to the biocompatibility of the native cement. ## Claims ### Claim 1 An antimicrobial bone cement, comprising: a dry mixture including a dry component and nanostructured antimicrobial silver perovskite particles, wherein a weight of the nanostructured antimicrobial silver perovskite particles is in a range of 1% to 10% of a total weight of the antimicrobial bone cement; and the nanostructured antimicrobial silver perovskite particles having a specific surface area of at least 1 m2/g and a silver release rate of less than 0.1% of the total weight over 24 hours into deionized water at room temperature. ### Claim 2 (depends on 1) The antimicrobial bone cement of claim 1, wherein the nanostructured antimicrobial silver perovskite particles is AgNbO3. ### Claim 3 (depends on 1) The antimicrobial bone cement of claim 1, wherein the nanostructured antimicrobial silver perovskite particles is AgTaO3. ### Claim 4 (depends on 1) The antimicrobial bone cement of claim 1, wherein the specific surface area of the nanostructured antimicrobial silver perovskite particles is 1 m2/g to 40 m2/g. ### Claim 5 (depends on 1) The antimicrobial bone cement of claim 1, wherein the specific surface area of the nanostructured antimicrobial silver perovskite particles is 2 m2/g to 20 m2/g. ### Claim 6 (depends on 1) The antimicrobial bone cement of claim 1, wherein the specific surface area of the nanostructured antimicrobial silver perovskite particles is 4 m2/g to 10 m2/g. ### Claim 7 (depends on 1) The antimicrobial bone cement of claim 1, wherein the weight of the nanostructured antimicrobial silver perovskite particles is 1% to 8% of the total weight of the antimicrobial bone cement. ### Claim 8 (depends on 1) The antimicrobial bone cement of claim 1, wherein the weight of the nanostructured antimicrobial silver perovskite particles is 1% to 4% of the total weight of the antimicrobial bone cement. ### Claim 9 (depends on 1) The antimicrobial bone cement of claim 1, wherein the antimicrobial bone cement is polymethyl methacrylate (PMMA). ### Claim 10 (depends on 1) The antimicrobial bone cement of claim 1, wherein the dry component consists of an acrylic polymer and a polymerization initiator. ### Claim 11 (depends on 1) The antimicrobial bone cement of claim 1, further comprising a liquid component which is added to the mixture of the dry component and the nanostructured antimicrobial silver perovskite particles to form the antimicrobial bone cement. ### Claim 12 (depends on 11) The antimicrobial bone cement of claim 11, wherein the liquid component consists of an acrylic monomer and a polymerization inhibitor. ### Claim 13 (depends on 1) The antimicrobial bone cement of claim 1, wherein the nanostructured antimicrobial silver perovskite particles exhibit long-lasting, broad-spectrum antimicrobial activity. ### Claim 14 (depends on 13) The antimicrobial bone cement of claim 13, wherein the nanostructured antimicrobial silver perovskite particles maintain their antimicrobial activity after long-term exposure to an external environment. ### Claim 15 (depends on 1) The antimicrobial bone cement of claim 1, wherein the nanostructured antimicrobial silver perovskite particles have a relative silver release rate (RSRR) of less than 20%. ### Claim 16 (depends on 1) The antimicrobial bone cement of claim 1, wherein the nanostructured antimicrobial silver perovskite particles have a relative silver release rate (RSRR) of 1% to 15%. ### Claim 17 (depends on 1) The antimicrobial bone cement of claim 1, wherein antimicrobial activity of the nanostructured antimicrobial silver perovskite particles is mediated by continuous change in silver oxidation valence in proximity to microorganisms. ### Claim 18 (depends on 1) A method for preparing the antimicrobial bone cement of claim 1, comprising: adding a liquid component to the dry mixture of the dry component and the nanostructured antimicrobial silver perovskite particles. ### Claim 19 (depends on 18) The method of claim 18, wherein the dry component and the nanostructured antimicrobial silver perovskite particles are pre-packaged together. ### Claim 20 (depends on 1) A method for preparing the antimicrobial bone cement of claim 1 for application, the method comprising: providing the dry component comprising polymethyl methacrylate particles and a polymerization initiator; providing a liquid component comprising a liquid monomer of methyl methacrylate, an accelerator, and a stabilizer; providing the nanostructured antimicrobial silver perovskite particles having the specific surface area of at least 1 m2/g and the silver release rate of less than 0.1% of their total weight over 24 hours into the deionized water at room temperature; and premixing the nanostructured antimicrobial silver perovskite particles with the dry component to form the dry mixture, wherein the dry mixture and the liquid component are configured to be mixed in an operation room immediately before application of the antimicrobial bone cement.