Methods for increasing shelf-life of ophthalmic pharmaceutical compositions

A method for extending the shelf life of a sterile, preservative-free, ophthalmic pharmaceutical composition, the method comprising:

• autoclaving a first phase composition consisting of prednisolone or a pharmaceutically acceptable salt thereof, sodium acetate, sodium chloride polyoxyethylene sorbitan monooleate, hydroxypropyl methylcellulose, optionally hydrochloric acid, optionally sodium hydroxide, and water;
• autoclaving or sterile filtering a second phase composition consisting of moxifloxacin, bromfenac, sodium phosphate, sodium metabisulfite, edetate disodium, boric acid, sodium borate, optionally hydrochloric acid, optionally sodium hydroxide, and water;
• and
• combining the first phase composition and the second phase composition, aseptically,
• wherein the ophthalmic pharmaceutical composition has a shelf life that is at least 90 days when stored at room temperature.