Methods and compositions for treatment of pancreatic cancer
OwnerVinod Balachandran, Taha Merghoub +1inventors
InventorsVinod Balachandran, Taha Merghoub, John Alec Moral
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Abstract
The present invention provides various compositions and methods useful for the treatment of pancreatic cancer, such as pancreatic ductal adenocarcinoma (PDAC), and methods for activating pancreatic tissue-specific anti-tumor T cell immunity. In some embodiments such methods involve administration of IL33. In some embodiments such methods involve administration of a PD-1 and/or PD-L1 inhibitor.
Claims9
A method of treating pancreatic ductal adenocarcinoma (PDAC) in a subject in need thereof, the method comprising administering to a subject with PDAC an effective amount of IL33, thereby treating the PDAC in the subject.
A pharmaceutical composition comprising:
- (a) IL33 and (b) a PD-1 and/or PD-L1 inhibitor.
Dependencies are inferred from the claim text.