# US 12,594,310 B2 · Composition comprising lactic acid bacteria derived from green tea for improving liver function

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- Number: US 12,594,310 B2
- Document ID: US12594310B2
- Status: Granted
- Kind: B2
- Application number: 18/313,465
- Filed: 2023-05-08
- Published: 2023-11-23
- Granted: 2026-04-07
- Earliest claimed: 2022-05-18
- Assignees: Amorepacific Corporation
- Applicants: Amorepacific Corporation
- Inventors: Hyun Woo Jeong; Donghyun Cho; Wanki Kim; Jong Hwa Roh
- Web page: https://patentgrep.com/patent/US12594310B2

## CPC

- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A61K 35/747: Lactobacilli, e.g. L. acidophilus or L. brevis
- A61P 1/16: for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- C12N 1/20: Bacteria; Culture media therefor
- C12N 1/205: Bacterial isolates
- A23V 2400/169: Plantarum
- C12R 2001/25: Lactobacillus plantarum
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS

## Abstract

A method for improving hepatic function, including administering an effective amount of a composition including a green tea-derived Lactiplantibacillus plantarum strain; a culture of the strain; a lysate of the strain; an extract of the strain; an extract of the culture; or an extract of the lysate to a subject in need thereof is disclosed in the specification.

## Claims

### Claim 1

A method for improving hepatic function, comprising administering an effective amount of a composition comprising a green tea-derived Lactiplantibacillus plantarum APsulloc 331261 strain (Accession No.: KCCM11179P); or a lysate of the strain to a subject in need thereof, wherein the improvement of the hepatic function comprises at least one of: alleviating or treating fatty liver; inhibiting fat accumulation in a hepatocyte; and inhibiting oxidative stress in a hepatocyte.

### Claim 2 (depends on 1)

The method of claim 1, wherein the fatty liver comprises at least one of an alcoholic fatty liver and a non-alcoholic fatty liver.

### Claim 3 (depends on 1)

The method of claim 1, wherein the strain is a non-viable strain.

### Claim 4 (depends on 1)

The method of claim 1, wherein the composition is administered orally.

### Claim 5 (depends on 1)

The method of claim 1, wherein the composition is a food composition.

### Claim 6 (depends on 1)

The method of claim 1, wherein the composition is a pharmaceutical composition.