# US 12,594,296 B2 · Methods for treatment or prevention of damage resulting from radiation, trauma or shock

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 12,594,296 B2
- Document ID: US12594296B2
- Status: Granted
- Kind: B2
- Application number: 18/430,984
- Filed: 2024-02-02
- Published: 2025-01-02
- Granted: 2026-04-07
- Earliest claimed: 2012-09-20
- Assignees: Synedgen, Inc.
- Applicants: Synedgen, Inc.
- Inventors: Shenda M. Baker; William P. Wiesmann
- Web page: https://patentgrep.com/patent/US12594296B2

## CPC

- A61K 31/726: Glycosaminoglycans, i.e. mucopolysaccharides (chondroitin sulfate, dermatan sulfate A61K31/737)
- A61P 17/02: for treating wounds, ulcers, burns, scars, keloids, or the like
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

Described herein are methods of treating a subject that has been or will be exposed to radiation, trauma or shock, the method comprising identifying a subject that has been or will be exposed to radiation, and treating the subject with a compound that treats, reduces the severity or delays the onset of sepsis or reduces the likelihood of mortality in a subject upon administration of a therapeutically effective amount the compound to the subject.

## Claims

### Claim 1

A method of reducing the severity or delaying the onset of sepsis or reducing the likelihood of mortality in a subject, the method comprising identifying a subject that will be exposed to radiation from a dirty bomb, accidental nuclear incident, or therapeutic treatment; and prior to exposure to radiation, administering a therapeutically effective amount of a compound to the subject,
wherein the compound is a compound of Formula (I):
wherein:
n is an integer between 20 and 6000; and
each R1 is independently selected for each occurrence from hydrogen, acetyl,
wherein at least 25% of R1 substituents are H, at least 1% of R1 substituents are acetyl,
and at least 2% of R1 substituents are
thereby reducing the severity or delaying the onset of sepsis or reducing the likelihood of mortality in the subject.

### Claim 2 (depends on 1)

The method of claim 1, wherein the subject is at risk of developing sepsis as a result of exposure to radiation.

### Claim 3 (depends on 1)

The method of claim 1, wherein the subject has or is at risk of having reduced nutrient absorption, pain, nausea, diarrhea, and/or weight loss resulting from radiation.

### Claim 4 (depends on 1)

The method of claim 1, wherein the subject has necrotizing enterocolitis, necrotic enteritis, short bowel syndrome, or short gut syndrome.

### Claim 5 (depends on 1)

The method of claim 1, wherein the compound is functionalized at between 18% and 30%.

### Claim 6 (depends on 1)

The method of claim 1, wherein the molecular weight of the compound is from 50 to 150 kDa.

### Claim 7 (depends on 1)

The method of claim 1, wherein the polydispersity index of the compound is from 1.0 to 2.5.

### Claim 8 (depends on 1)

The method of claim 1, wherein the radiation is in an amount sufficient to produce 30% to 80% lethality.

### Claim 9 (depends on 1)

The method of claim 1, wherein the radiation is from a dirty bomb or accidental nuclear incident.

### Claim 10 (depends on 1)

The method of claim 1, wherein the radiation is from therapeutic treatment.

### Claim 11 (depends on 10)

The method of claim 10, wherein the therapeutic treatment is bone marrow transplant therapy.