IP and IP analogs dosage regimens for the treatment of ectopic calcifications
AssigneeSanifit Therapeutics S.A.
InventorsJoan Perello Bestard, Carolina Salcedo Roca, Ana-Zeralda Canals Hamann
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Abstract
The present disclosure related to compositions, methods, dosages, dosage regimens, articles of manufacture and kits for the treatment and/or prevention ectopic calcifications, and in particular cutaneous calcifications such as calciphylaxis calcifications comprising inositol phosphate, inositol phosphate analogs, inositol phosphate derivatives, or combinations thereof. In a particular aspect the disclosure provides a dosage regimen to treat calciphylaxis comprising the administration of 6 mg/kg to 9 mg/kg daily doses of myo-inositol hexaphosphate, three times a week, for at least 1 to 8 months.
Claims21
A method of treating or inhibiting the occurrence of aortic stenosis in a human subject in need thereof, comprising administering a dosage of about 5 mg to 10 mg of SNF472 (hexasodium salt of myo-inositol hexaphosphate) per kg per day, wherein the administration of the dosage effectively treats or inhibits the occurrence of aortic stenosis in the subject.
Dependencies are inferred from the claim text.