# US 12,594,234 B2 · Use of an epilobium fleischeri extract > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,594,234 B2 - Document ID: US12594234B2 - Status: Granted - Kind: B2 - Application number: 18/026,681 - Filed: 2021-09-17 - Published: 2023-11-02 - Granted: 2026-04-07 - Earliest claimed: 2020-09-25 - Assignees: Dsm IP Assets B.V. - Applicants: Dsm IP Assets B.V. - Inventors: Joshua Claypool; Dominik Imfeld; Riccardo Sfriso - Web page: https://patentgrep.com/patent/US12594234B2 ## CPC - A61K 8/9789: Magnoliopsida [dicotyledons] - A61Q 17/00: Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings - A61Q 19/00: Preparations for care of the skin - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract The present invention relates to an Epilobium extract, preferably an Epilobium fleischeri extract for use as a prebiotic. ## Claims ### Claim 1 A method to increase the differential abundance of at least one microbe selected from the group consisting of Staphylococcus hominis, Staphylococcus epidermidis; Micrococcus yunnanensis, Cutibacterium granulosum, and Corynebacterium accolens, in the skin microbiome of an individual in need thereof, the method comprising the step of topically administering an effective amount of an Epilobium extract to an external surface of the individual in need thereof. ### Claim 2 (depends on 1) The method according to claim 1, wherein the method comprises simultaneously reducing the differential abundance of at least one microbe selected from the group consisting of Staphylococcus capitis; Corynebacterium tuberculostearicum; Lawsonella clevelandensis, Staphylococcus aureus and Corynebacterium kroppenstedtii. ### Claim 3 (depends on 1) The method according to claim 1, wherein the Epilobium extract is an Epilobium fleischeri extract, an Epilobium Angustifolium extract or an Epilobium Parviflorum extract. ### Claim 4 (depends on 3) The method according to claim 3, wherein the Epilobium extract is an Epilobium fleischeri extract. ### Claim 5 (depends on 1) The method according to claim 1, wherein the Epilobium extract is an aqueous extract obtained from the flowers, leaves and/or stems of an Epilobium plant. ### Claim 6 (depends on 1) The method according to claim 1, wherein the external surface of the individual in need thereof is at least one of skin, scalp, an axilla cavity and oral cavity. ### Claim 7 (depends on 1) The method according to claim 1, wherein the method comprises administering the Epilobium extract in the form of a topical composition comprising an effective amount of the Epilobium extract and a cosmetically acceptable carrier. ### Claim 8 (depends on 7) The method according to claim 7, wherein the topical composition comprises from 0.001 to 10 wt % of the Epilobium extract, based on the total weight of the topical composition. ### Claim 9 (depends on 8) The method according to claim 8, wherein the topical composition comprises from 0.1 to 5 wt % of the Epilobium extract, based on the total weight of the topical composition. ### Claim 10 (depends on 8) The method according to claim 8, wherein the topical composition is a leave-on composition. ### Claim 11 (depends on 1) The method according to claim 1, wherein the method is non-therapeutic. ### Claim 12 A method for providing protection to an external surface of the human body by increasing the differential abundance of at least one microbe selected from the group consisting of Staphylococcus hominis, Staphylococcus epidermidis, Micrococcus yunnanensis; Cutibacterium granulosum and Corynebacterium accolens in the skin microbiome of an individual in need thereof, the method comprising the step of applying an Epilobium extract to the external surface of the individual in need thereof. ### Claim 13 (depends on 12) The method according to claim 12, wherein the method comprises simultaneously reducing the differential abundance of at least one microbe selected from the group consisting of Staphylococcus capitis; Corynebacterium tuberculostearicum; Lawsonella clevelandensis, Staphylococcus aureus and Corynebacterium kroppenstedtii. ### Claim 14 (depends on 12) The method according to claim 12, wherein the Epilobium extract is an Epilobium fleischeri extract, an Epilobium Angustifolium extract or an Epilobium Parviflorum extract. ### Claim 15 (depends on 14) The method according to claim 14, wherein the Epilobium extract is an Epilobium fleischeri extract. ### Claim 16 (depends on 12) The method according to claim 12, wherein the Epilobium extract is an aqueous extract obtained from the flowers, leaves and/or stems of an Epilobium plant. ### Claim 17 (depends on 12) The method according to claim 12, wherein the external surface of the human body in need thereof is at least one of skin, scalp, an axilla cavity and oral cavity. ### Claim 18 (depends on 12) The method according to claim 12, wherein the method comprises administering the Epilobium extract in the form of a topical composition comprising an effective amount of the Epilobium extract and a cosmetically acceptable carrier. ### Claim 19 (depends on 18) The method according to claim 18, wherein the topical composition comprises from 0.001 to 10 wt % of the Epilobium extract, based on the total weight of the topical composition. ### Claim 20 (depends on 18) The method according to claim 18, wherein the topical composition is a leave-on composition. ### Claim 21 (depends on 12) The method according to claim 12, wherein the method is non-therapeutic.