Ultrasound device for use with synthetic cavitation nuclei

An ultrasound device comprising:

• an ultrasound transducer assembly comprising:
• a plurality of ultrasound transducer elements arranged in an array and contained within an external housing;
• and
• a multi-channel amplifier circuit, wherein each channel of the multi-channel amplifier circuit is configured to actuate a distinct subset of the plurality of ultrasound transducer elements,
• wherein the multi-channel amplifier circuit is configured to operate in each of a plurality of states, each state of the plurality of states comprising a set of frequencies, each set of frequencies comprising a frequency at which each channel of the multichannel amplifier circuit is configured to actuate the distinct subset of the plurality of ultrasound transducer elements, and
• wherein the multi-channel amplifier circuit is configured to switch between the plurality of states, thereby causing the plurality of ultrasound transducer elements to produce a frustum-shaped beam,
• wherein the frustum-shaped beam comprises a plurality of longitudinal acoustic waves, each longitudinal acoustic wave of the plurality of longitudinal acoustic waves produced by one of the plurality of ultrasound transducer elements, and constructive and destructive interference of the longitudinal acoustic waves yields approximately uniform peak pressures throughout a frustum-shaped volume, and wherein the peak pressures are within 50% of a global maximum peak pressure within the volume.