# US 12,594,051 B2 · Ultrasound microvasculature super-resolution imaging acquisition > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,594,051 B2 - Document ID: US12594051B2 - Status: Granted - Kind: B2 - Application number: 18/346,630 - Filed: 2023-07-03 - Published: 2025-01-09 - Granted: 2026-04-07 - Earliest claimed: 2023-07-03 - Assignees: Fujifilm Sonosite, Inc. - Applicants: FUJIFILM SonoSite, Inc. - Inventors: Christopher White - Web page: https://patentgrep.com/patent/US12594051B2 ## CPC - A61B 8/06: Measuring blood flow - A61B 8/488: {involving Doppler signals} - A61B 8/5207: {involving processing of raw data to produce diagnostic data, e.g. for generating an image} - A61B 8/5223: {for extracting a diagnostic or physiological parameter from medical diagnostic data (for algorithms to analyse biomedical images G06T7/0012)} - A61B 8/5269: {involving detection or reduction of artifacts} - A61B 8/5284: {involving retrospective matching to a physiological signal} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract Systems and methods for microvasculature imaging acquisition are disclosed. In aspects, a full frame corresponding to a field of view of an ultrasound scanner is divided into small portions, each of which is individually scanned for a desired period of time at a higher frame rate than the ultrasound scanner is capable of using to scan the full frame. These ultrasound data acquisition techniques enable super-resolution image processing or high-sensitivity microvascular-doppler image processing to be used to track low-intensity, slow-flow microvasculature of an anatomy of a subject. ## Claims ### Claim 1 A method comprising: generating first ultrasound data based on reflections of first ultrasound signals transmitted by an ultrasound scanner of an ultrasound system at an anatomy of a subject, the ultrasound scanner having a predefined pulse repetition frequency (PRF) for emitting the first ultrasound signals, the ultrasound scanner having a maximum frame rate for producing multiple frames of image data from the first ultrasound data over a sector corresponding to a full field of view (FOV) of the ultrasound scanner, the sector having a width corresponding to an image width of the multiple frames, the maximum frame rate being based on the predefined PRF and a number of acquisition lines corresponding to each frame of the image data; responsive to an input, increasing a temporal resolution of the ultrasound system by: dividing the sector into a plurality of portions that each have fewer acquisition lines than the sector; causing the ultrasound scanner to transmit second ultrasound signals within a respective portion of the plurality of portions repeatedly for a duration of a line-time and at the predefined PRF to achieve a greater frame rate for the respective portion than the maximum frame rate for the sector, wherein the second ultrasound signals are transmitted repeatedly within a first portion of the plurality of portions for the duration of the line-time prior to being transmitted repeatedly within a second portion of the plurality of portions for the duration of the line-time; generating second ultrasound data based on reflections of the second ultrasound signals; and between acquisition of two respective portions of the plurality of portions, acquiring a scout image of the full FOV of the ultrasound scanner and inserting the scout image into a frame sequence of the acquisition of the two respective portions; tracking slow-flow microvasculature of the anatomy in each portion by executing super-resolution image processing or microvascular-doppler image processing on the second ultrasound data for each portion; compounding results of the super-resolution image processing or the microvascular-doppler image processing for each portion to provide compounded results for the sector; and generating, based on the compounded results, the image data for rendering an image representing the slow-flow microvasculature of the anatomy over the sector. ### Claim 2 (depends on 1) The method of claim 1, wherein the second ultrasound data is generated using standard imaging protocols that provide one acquisition line per transmit pulse. ### Claim 3 (depends on 1) The method of claim 1, wherein the second ultrasound data is generated using imaging protocols that provide two acquisition lines per transmit pulse. ### Claim 4 (depends on 1) The method of claim 1, wherein at least some of the second ultrasound signals transmitted by the ultrasound scanner include one or more steered transmit beams for generating at least some of the second ultrasound data at one or more different directions that are non-parallel to an axial direction of the ultrasound scanner. ### Claim 5 (depends on 1) The method of claim 1, wherein at least some of the portions are aligned relative to an axial direction of the ultrasound scanner. ### Claim 6 (depends on 1) The method of claim 1, further comprising synchronizing the second ultrasound data with physiological signals of the subject. ### Claim 7 (depends on 1) The method of claim 1, further comprising: transmitting the second ultrasound signals at the anatomy repeatedly for the duration of the line-time over the respective portion of the plurality of portions and at the predefined PRF; and receiving the reflections of the second ultrasound signals. ### Claim 8 (depends on 1) The method of claim 1, wherein generating the second ultrasound data includes generating the second ultrasound data for each portion of the plurality of portions individually and separately from other portions of the plurality of portions. ### Claim 9 (depends on 1) The method of claim 1, wherein executing the super-resolution image processing or the microvascular-doppler image processing includes filtering out reflected ultrasound signals representing stationary tissue of the anatomy. ### Claim 10 (depends on 1) The method of claim 1, wherein at least two portions of the plurality of portions are non-overlapping. ### Claim 11 (depends on 1) The method of claim 1, wherein at least one portion of the plurality of portions overlaps a boundary of at least one other portion of the plurality of portions. ### Claim 12 (depends on 1) The method of claim 1, further comprising providing displayable real-time updates of the anatomy of the subject based on periodic scout images acquired between the portions of the plurality of portions. ### Claim 13 An ultrasound system comprising: an ultrasound scanner having a predefined pulse repetition frequency (PRF) for emitting ultrasound signals and a maximum frame rate for producing multiple frames of image data from detected reflections of the ultrasound signals emitted over a sector corresponding to a full field of view (FOV) of the ultrasound scanner, the sector having a width corresponding to an image width of the multiple frames, the maximum frame rate being based on the predefined PRF and a number of acquisition lines corresponding to each frame of the image data, the ultrasound scanner configured to, in response to an input: divide the sector into a plurality of portions; transmit, at an anatomy of a subject, the ultrasound signals within a respective portion of the plurality of portions repeatedly for a duration of a line-time using the predefined PRF to achieve a frame rate for the respective portion that is greater than the maximum frame rate for the sector, the ultrasound signals transmitted repeatedly within a first portion of the plurality of portions for the duration of the line-time prior to being transmitted repeatedly within a second portion of the plurality of portions for the duration of the line-time; generate ultrasound data for the respective portion of the plurality of portions based on detected reflections of the ultrasound signals transmitted within the respective portion; and between acquisition of two respective portions of the plurality of portions, acquire a scout image of the full FOV of the ultrasound scanner and insert the scout image into a frame sequence of the acquisition of the two respective portions; one or more computer processors; and one or more computer-readable media having instructions stored thereon that, responsive to execution by the one or more computer processors, implement one or more modules, the one or more modules configured to: execute super-resolution image processing or microvascular-doppler image processing on the ultrasound data for each portion to provide image-processing results for tracking slow-flow microvasculature of the anatomy; and generate the image data for rendering an image representing the slow-flow microvasculature of the anatomy over the sector based on a combination of the image-processing results of the ultrasound data for each portion. ### Claim 14 (depends on 13) The ultrasound system of claim 13, wherein the ultrasound scanner is configured to steer at least some of the transmitted ultrasound signals in one or more directions that are non-parallel to an axial direction of the ultrasound scanner. ### Claim 15 (depends on 13) The ultrasound system of claim 13, wherein the one or more modules are configured to synchronize the ultrasound data with physiological signals of the subject. ### Claim 16 (depends on 13) The ultrasound system of claim 13, wherein the one or more modules are further configured to compound the image-processing results of the ultrasound data for each portion to generate the image data of the slow-flow microvasculature over the sector. ### Claim 17 (depends on 13) The ultrasound system of claim 13, wherein the frame rate is equal to or greater than 1,000 frames per second and the ultrasound data is generated at one line per transmit pulse by the ultrasound scanner. ### Claim 18 (depends on 13) The ultrasound system of claim 13, wherein the plurality of portions includes at least two non-overlapping portions. ### Claim 19 A method comprising: acquiring, by an ultrasound system having an ultrasound scanner with a fixed pulse repetition frequency (PRF) for emitting ultrasound signals, a first subset of a full set of data acquisition lines corresponding to a frame of image data, the first subset acquired repeatedly for a first line-time using a first frame rate and the fixed PRF to generate first ultrasound data, the ultrasound data representing reflections of the ultrasound signals transmitted by the ultrasound scanner at an anatomy of a subject, the first subset having fewer data acquisition lines than the full set; after acquiring the first subset of the full set of data acquisition lines, acquiring a scout image of the full set of data acquisition lines; after acquiring the scout image, acquiring, by the ultrasound system and independent of the first subset of the data acquisition lines, a second subset of the full set of data acquisition lines corresponding to the frame of image data, the second subset acquired repeatedly for a second line-time period using a second frame rate and the fixed PRF to generate second ultrasound data, the second subset having fewer data acquisition lines than the full set; inserting the scout image into a frame sequence of the first subset and the second subset; tracking slow-flow microvasculature of the anatomy by executing super-resolution image processing or microvascular-doppler image processing on the first ultrasound data and the second ultrasound data; and generating image data representing the slow-flow microvasculature of the anatomy based on a combination of image-processing results for the first ultrasound data and the processed second ultrasound data. ### Claim 20 (depends on 19) The method of claim 19, wherein the acquiring of the second subset is initiated after expiration of the first line-time. ### Claim 21 (depends on 19) The method of claim 19, wherein: acquiring the first subset includes using steered transmit beams to acquire at least some of the first subset at one or more directions that are non-parallel to an axial direction of the ultrasound scanner; and acquiring the second subset includes using steered transmit beams to acquire at least some of the second subset at one or more directions that are non-parallel to the axial direction of the ultrasound scanner.