# US 12,594,028 B1 · EEG montage for facilitating selection of drug treatment in patients suffering from psychiatric disorders > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,594,028 B1 - Document ID: US12594028B1 - Status: Granted - Kind: B1 - Application number: 19/047,415 - Filed: 2025-02-06 - Granted: 2026-04-07 - Earliest claimed: 2025-02-06 - Assignees: Alto Neuroscience, Inc. - Applicants: Alto Neuroscience, Inc. - Inventors: Amit Etkin; Sarah Long; Iliana Bray; Akshay Sujatha Ravindran - Web page: https://patentgrep.com/patent/US12594028B1 ## CPC - A61B 5/4848: {Monitoring or testing the effects of treatment, e.g. of medication} - A61B 5/165: {Evaluating the state of mind, e.g. depression, anxiety} - A61B 5/271: Arrangements of electrodes with cords, cables or leads, e.g. single leads or patient cord assemblies - A61B 5/291: for electroencephalography [EEG] - A61B 5/369: Electroencephalography [EEG] - A61B 5/374: Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves - A61B 5/6803: {Head-worn items, e.g. helmets, masks, headphones or goggles} - A61B 5/6814: {Head} - A61B 5/7275: {Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor} - A61K 31/165: having aromatic rings, e.g. colchicine, atenolol, progabide - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract This invention relates to the use of a reduced number of electroencephalogram (EEG) channels for predicting those who would benefit from drug treatment (such as with agomelatine) in patients with a psychiatric disorder (such as depression), as well as to an electroencephalogram (EEG) device for recording EEG data at these EEG channels. ## Claims ### Claim 1 A method of selecting a patient suffering from depression for an agomelatine treatment and treating the patient, the method comprising: collecting brain wave activity data via a configuration of EEG electrodes applied to the patient, wherein the configuration is a 7-channel electrode configuration consisting of EEG electrodes at: F7-Fz-F8-Cz-P7-Pz-P8, according to the 10-10 system of electrode placement; analyzing the brain wave activity data to calculate one or more EEG measures, wherein at least one of the one or more EEG measures are selected from a group consisting of: an EEG measure of entropy, an EEG measure of complexity, or any combination thereof; predicting an outcome of the agomelatine treatment in the patient based on the one or more EEG measures; selecting the patient for agomelatine treatment based on the outcome prediction; and when the patient is selected for agomelatine treatment based on the one or more EEG measures, administering an effective amount of agomelatine, a prodrug thereof, or a pharmaceutically acceptable salt thereof to treat the depression of the patient. ### Claim 2 (depends on 1) The method of claim 1, wherein at least one of the one or more EEG measures comprises EEG sample entropy. ### Claim 3 (depends on 1) The method of claim 1, wherein at least one of the one or more EEG measures comprises EEG sample entropy at the Pz electrode. ### Claim 4 (depends on 3) The method of claim 3, wherein a signal from the Pz electrode is re-referenced using a common average reference from the 7 EEG electrodes in the 7-channel configuration, and wherein the sample entropy is calculated after the signal from the Pz electrode is re-referenced. ### Claim 5 (depends on 1) The method of claim 1, wherein at least one of the one or more EEG measures are selected from a group consisting of: measures of predictability, measures of regularity, or any combination thereof. ### Claim 6 (depends on 1) The method of claim 1, wherein at least one of the one or more EEG measures are selected from a group consisting of: approximate entropy, detrended fluctuation analysis, Higuchi fractal dimension, Katz fractal dimension, largest Lyapunov exponent, modified multiscale entropy, multiscale entropy, aperiodic exponent, or any combination thereof. ### Claim 7 (depends on 1) The method of claim 1, wherein the one or more EEG measures are analyzed with stored historical subject data containing data from a plurality of subjects having a depressive disorder, who received treatment with agomelatine, a prodrug thereof, or a pharmaceutically acceptable salt thereof, and wherein the stored historical subject data includes, for the plurality of the subjects, the efficacy of the agomelatine treatment and one or more of the same type of EEG measures as calculated for the patient. ### Claim 8 (depends on 7) The method of claim 7, wherein the step of predicting an outcome of the agomelatine treatment in the patient comprises determining an agomelatine efficacy likelihood score for the patient based on the stored historical subject data, and wherein the step of selecting the patient for agomelatine treatment based on the outcome prediction comprises selecting the patient based on the likelihood score.