# US 12,594,027 B2 · Mediation of traumatic brain injury > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 12,594,027 B2 - Document ID: US12594027B2 - Status: Granted - Kind: B2 - Application number: 18/139,230 - Filed: 2023-04-25 - Published: 2023-09-28 - Granted: 2026-04-07 - Earliest claimed: 2017-10-31 - Assignees: StimScience Inc. - Applicants: StimScience Inc. - Inventors: Anantha Pradeep - Web page: https://patentgrep.com/patent/US12594027B2 ## CPC - A61B 5/4836: {Diagnosis combined with treatment in closed-loop systems or methods (A61B5/0036 takes precedence)} - A61B 5/37: Intracranial electroencephalography [IC-EEG], e.g. electrocorticography [ECoG] - A61B 5/383: Somatosensory stimuli, e.g. electric stimulation - A61B 5/4094: {Diagnosing or monitoring seizure diseases, e.g. epilepsy} - A61B 5/74: {Details of notification to user or communication with user or patient; User input means} - A61M 21/00: Other devices or methods to cause a change in the state of consciousness; Devices for producing or ending sleep by mechanical, optical, or acoustical means, e.g. for hypnosis - A61N 2/006: {for magnetic stimulation of nerve tissue} - A61B 5/378: Visual stimuli - A61B 5/38: Acoustic or auditory stimuli - A61B 5/4064: {Evaluating the brain (for intracranial pressure A61B5/031; for cerebral blood gases A61B5/14553; using EEG A61B5/369)} - A61B 5/7267: {involving training the classification device} - A61M 21/02: for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia (for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021) - A61M 2021/0022: {by the tactile sense, e.g. vibrations} - A61M 2021/0027: {by the hearing sense} - A61M 2021/0044: {by the sight sense} - A61M 2021/005: {images, e.g. video} - A61M 2021/0072: {with application of electrical currents} - A61M 2205/3507: with implanted devices, e.g. external control - A61M 2205/3553: remote, e.g. between patient's home and doctor's office - A61M 2205/3584: using modem, internet or Bluetooth® - A61M 2205/50: with microprocessors or computers - A61M 2230/10: Electroencephalographic signals - A61N 1/0534: {Electrodes for deep brain stimulation} - A61N 1/36135: {using physiological parameters} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) ## Abstract Provided are systems, methods, and devices for providing mediation of a traumatic brain injury. Systems may include an interface, processing devices, and a controller. The interface is configured to obtain measurements from a brain of a user with a traumatic brain injury. A first processing device is configured to generate multiple brain state parameters characterizing one or more features of a brain state of the user. A second processing device is configured to generate models of the brain of the user based on the plurality of brain state parameters and the plurality of measurements, and determine, using the models and training data comprising one or more mediation data points, a mediation procedure for reducing one or more symptoms of the traumatic brain injury. The mediation procedure is provided to one or more entities, and one or more control signals are generated by the controller based on the mediation procedure. ## Claims ### Claim 1 A system comprising: one or more electrodes configured to be positioned on a user's scalp and electrically stimulate a brain of the user; an interface configured to obtain a plurality of measurements from a brain of a user with the one or more electrodes; a processing device configured to: generate a plurality of brain state parameters characterizing one or more features of at least one brain state of the user, and train a neural network to generate one or more models of the brain of the user, wherein the neural network is trained using training data generated, at least in part, from one or more mediation data points, the plurality of brain state parameters, and the plurality of measurements, wherein a procedure for therapeutic mediation is determined using at least the one or more models, the procedure for mediation configured to mitigate a therapeutic or cognitive condition or impairment; and a controller configured to generate one or more control signals to electrically stimulate the brain of the user to mitigate the cognitive condition or impairment, wherein the one or more control signals are generated based on the procedure for mediation, wherein the one or more electrodes provide electrical stimuli to the brain based on the control signals. ### Claim 2 (depends on 1) The system of claim 1, wherein the plurality of measurements represents neural activity of the brain over a given period of time. ### Claim 3 (depends on 1) The system of claim 1, wherein the plurality of brain state parameters includes deterministic and stochastic observers and estimators of one or more brain states. ### Claim 4 (depends on 1) The system of claim 1, wherein the plurality of brain state parameters includes a learning estimator model configured to estimate effects of behavioral or functional responses. ### Claim 5 (depends on 1) The system of claim 1, wherein the processing device is further configured to: generate diagnostic information based on the one or more models; and transmit a notification message including the diagnostic information to one or more entities. ### Claim 6 (depends on 1) The system of claim 1, further comprising an embedded prosthetic device implanted in the user, wherein the embedded prosthetic device is configured to perform the electrical stimulation of the brain of the user based on the one or more control signals. ### Claim 7 (depends on 6) The system of claim 6, wherein the embedded prosthetic device is communicatively coupled to the interface. ### Claim 8 (depends on 6) The system of claim 6, wherein the controller is further configured to update the control signals transmitted to the embedded prosthetic device based on updated measurements obtained by the interface after the electrical stimulation is performed on the brain of the user. ### Claim 9 (depends on 6) The system of claim 6, wherein the embedded prosthetic device is activated by the controller in response to detection or identification of one or more of the plurality of brain state parameters. ### Claim 10 A method comprising: obtaining a plurality of measurements from a brain of a user, wherein the plurality of measurements are obtained by an interface with one or more electrodes positioned on a scalp of the user; generating, via a processing device, a plurality of brain state parameters characterizing one or more features of at least one brain state of the user; training, via the processing device, a neural network to generate one or more models of the brain of the user, wherein the neural network is trained using training data generated, at least in part, from one or more mediation data points, the plurality of brain state parameters, and the plurality of measurements, wherein a procedure for therapeutic mediation is determined using at least the one or more models, the procedure for mediation configured to mitigate a cognitive condition or impairment; generating, via a controller, one or more control signals to electrically stimulate the brain of the user to mitigate the cognitive condition or impairment, wherein the one or more control signals are generated based on the procedure for mediation; and electrically stimulating the brain, with the one or more electrodes, based on the one or more control signals. ### Claim 11 (depends on 10) The method of claim 10, wherein the plurality of measurements represent neural activity of the brain over a given period of time. ### Claim 12 (depends on 10) The method of claim 10, wherein the plurality of brain state parameters includes deterministic and stochastic observers and estimators of one or more brain states. ### Claim 13 (depends on 10) The method of claim 10, wherein the plurality of brain state parameters includes a learning estimator model configured to estimate effects of behavioral or functional responses. ### Claim 14 (depends on 10) The method of claim 10, further comprising: generating diagnostic information based on the one or more models; and transmitting a notification message including the diagnostic information to one or more entities. ### Claim 15 (depends on 10) The method of claim 10, further comprising performing, via an embedded prosthetic device implanted in the user, the electrical stimulation of the brain of the user based on the one or more control signals. ### Claim 16 (depends on 15) The method of claim 15, wherein the embedded prosthetic device is communicatively coupled to the interface. ### Claim 17 (depends on 15) The method of claim 15, further comprising updating the control signals transmitted to the embedded prosthetic device based on updated measurements obtained by the interface after the electrical stimulation is performed on the brain of the user. ### Claim 18 (depends on 15) The method of claim 15, wherein the embedded prosthetic device is activated by the controller in response to detection or identification of one or more of the plurality of brain state parameters. ### Claim 19 A non-transitory computer readable medium storing one or more programs configured for execution by a computer, the one or more programs comprising instructions for: obtaining a plurality of measurements from a brain of a user, wherein the plurality of measurements are obtained by an interface with one or more electrodes positioned on a scalp of the user; generating, via a processing device, a plurality of brain state parameters characterizing one or more features of at least one brain state of the user; training, via the processing device, a neural network to generate one or more models of the brain of the user, wherein the neural network is trained using training data generated at least in part, from one or more mediation data points, the plurality of brain state parameters, and the plurality of measurements, wherein a procedure for therapeutic mediation is determined using at least the one or more models, the procedure for mediation configured to mitigate a cognitive condition or impairment; generating, via a controller, one or more control signals to electrically stimulate the brain of the user to mitigate the cognitive condition or impairment, wherein the one or more control signals are generated based on the procedure for mediation; and electrically stimulating the brain, with the one or more electrodes, based on the one or more control signals. ### Claim 20 (depends on 19) The non-transitory computer readable medium of claim 19, wherein the one or more programs further comprise instructions for performing, via an embedded prosthetic device implanted in the user, the electrical stimulation the brain of the user based on the one or more control signals.