# US 12,594,010 B2 · Minimally invasive skin patch, method of manufacturing same, and blood glucose measuring apparatus using same

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- Number: US 12,594,010 B2
- Document ID: US12594010B2
- Status: Granted
- Kind: B2
- Application number: 17/511,506
- Filed: 2021-10-26
- Published: 2022-04-28
- Granted: 2026-04-07
- Earliest claimed: 2020-10-27
- Assignees: Electronics and Telecommunications Research Institute
- Applicants: Electronics and Telecommunications Research Institute
- Inventors: Hoe Sung Yang; Kang Bok Lee; Kwang Soo Cho; Kyu Won Han
- Web page: https://patentgrep.com/patent/US12594010B2

## CPC

- A61B 5/14532: {for measuring glucose, e.g. by tissue impedance measurement}
- A61B 5/0059: {using light, e.g. diagnosis by transillumination, diascopy, fluorescence (photoacoustic A61B5/0093; optical measurement of heart rate A61B5/02416; optical measurement of blood flow A61B5/0261; optical measurement of analytes A61B5/1455)}
- A61B 5/6833: {Adhesive patches}
- A61B 5/685: {Microneedles}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

In the invention, only light reflected by a portion in which a microneedle is disposed arrives on a photodetector, and light reflected by a portion in which the microneedle is not disposed does not arrive on the photodetector. Disclosed is a skin patch for measuring blood glucose including a patch including a skin attachment surface, a reaction layer which reacts with glycation products of skin, and a plurality of microneedles disposed on the skin attachment surface to guide the glycation products of the skin to the reaction layer and an optical trap which allows light, which is reflected by only one portion among a portion in which the microneedle is disposed and a portion in which the microneedle is not disposed when the light is emitted to the reaction layer, to pass therethrough, a method of manufacturing the same, and a blood glucose measuring apparatus using the same.

## Claims

### Claim 1

A skin patch for measuring blood glucose, comprising:
a patch comprising a skin attachment surface, a reaction layer which reacts with glycation products of skin, and a plurality of microneedles disposed on the skin attachment surface to guide the glycation products of the skin to the reaction layer; and
an optical trap disposed on the reaction layer, the optical trap allowing light, which is reflected by only one portion among a portion in which a microneedle of the plurality of microneedles is disposed and a portion in which the microneedle is not disposed when the light is emitted to the reaction layer, to pass therethrough, wherein the optical trap is on an upper surface of the patch opposite the skin attachment surface, and separated from the plurality of microneedles by a body of the patch between the upper surface and the skin attachment surface;
wherein the optical trap and the reaction layer extend across the plurality of microneedles in a direction orthogonal to a projection direction of the plurality of microneedles; and
wherein the optical trap comprises
light passing parts which allow light to pass therethrough, and
light blocking parts which block light, and
the light passing parts and the light blocking parts alternate in a planar pattern,
wherein the light passing parts and the light blocking parts are in contact with the upper surface of the reaction layer, and
wherein
each of the light passing parts aligns in the direction orthogonal to the projection direction of the plurality of microneedles with a corresponding microneedle of the plurality of microneedles and with one of first portions of the reaction layer having a concentration of the reactant expressed to be darker than a concentration of the reactant in second portions of the reaction layer, and
each of the light blocking parts aligns in the direction orthogonal to the projection direction of the plurality of microneedles with one of the second portions of the reaction layer and with a portion of the skin attachment surface that extends across a space between a pair of adjacent microneedles,
wherein
the reaction layer is at least partly within the body of the patch, and
the optical trap is outside the body of the patch and in direct contact with an upper surface of the reaction layer.

### Claim 2 (depends on 1)

The skin patch of claim 1, wherein:
the light passing parts allow light reflected by the portion, in which the microneedle is disposed, to pass therethrough; and
the light blocking parts block light reflected by the portion in which the microneedle is not disposed.

### Claim 3 (depends on 2)

The skin patch of claim 2, wherein a material of the optical trap is an opaque substrate and the light passing parts are holes formed in the opaque substrate and filled with a light passing material.

### Claim 4 (depends on 2)

The skin patch of claim 2, wherein a material of the optical trap is a transparent substrate and the light blocking parts comprise a light blocking material applied on a surface of the transparent substrate.

### Claim 5 (depends on 1)

The skin patch of claim 1, wherein:
the light blocking parts block light reflected by the portion in which the microneedle is disposed; and
the light passing parts allow light reflected by the portion in which the microneedle is not disposed to pass therethrough.

### Claim 6 (depends on 5)

The skin patch of claim 5, wherein a material of the optical trap is an opaque substrate and the light passing parts are holes formed in the opaque substrate and filled with a light passing material.

### Claim 7 (depends on 5)

The skin patch of claim 5, wherein a material of the optical trap is a transparent substrate and the light blocking parts comprise a light blocking material applied on a surface of the transparent substrate.

### Claim 8

A blood glucose measuring apparatus comprising:
a patch comprising a skin attachment surface, a reaction layer which reacts with glycation products of skin, and a plurality of microneedles disposed on the skin attachment surface to guide the glycation products of the skin to the reaction layer;
a reaction detector which emits light to the reaction layer and receives light reflected by the reaction layer to detect reactivity of the glycation products; and
an optical trap disposed on the reaction layer, the optical trap allowing only one ray of light to pass therethrough and arrive on the reaction detector, wherein the only one ray of light is reflected by the reaction layer of the patch and is one of light reflected by a portion in which a microneedle of the plurality of microneedles is disposed and light reflected by a portion in which the microneedle is not disposed, wherein the optical trap is on an upper surface of the patch opposite the skin attachment surface, and separated from the plurality of microneedles by a body of the patch between the upper surface and the skin attachment surface;
wherein the optical trap and the reaction layer extend across the plurality of microneedles in a direction orthogonal to a projection direction of the plurality of microneedles; and
wherein the optical trap comprises
light passing parts which allow light to pass therethrough, and
light blocking parts which block light, and
the light passing parts and the light blocking parts alternate in a planar pattern,
wherein the light passing parts and the light blocking parts are in contact with the upper surface of the reaction layer, and
wherein
each of the light passing parts aligns in the direction orthogonal to the projection direction of the plurality of microneedles with a corresponding microneedle of the plurality of microneedles and with one of first portions of the reaction layer having a concentration of the reactant expressed to be darker than a concentration of the reactant in second portions of the reaction layer, and
each of the light blocking parts aligns in the direction orthogonal to the projection direction of the plurality of microneedles with one of the second portions of the reaction layer and with a portion of the skin attachment surface that extends across a space between a pair of adjacent microneedles, and
wherein
the reaction layer is at least partly within the body of the patch, and
the optical trap is outside the body of the patch and in direct contact with an upper surface of the reaction layer.

### Claim 9 (depends on 8)

The blood glucose measuring apparatus of claim 8, wherein:
the light passing parts allows the light reflected by the portion, in which the microneedle is disposed, to pass therethrough and arrive on the reaction detector; and
the light blocking parts blocks the light reflected by the portion in which the microneedle is not disposed not to arrive on the reaction detector.

### Claim 10 (depends on 8)

The blood glucose measuring apparatus of claim 8, wherein:
the light blocking parts blocks the light reflected by the portion, in which the microneedle is disposed, not to arrive on the reaction detector; and
the light passing parts allows the light reflected by the portion in which the microneedle is not disposed to pass therethrough and arrive on the reaction detector.