# US 12,593,863 B2 · Probiotics to prevent cognitive dysfunction

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- Number: US 12,593,863 B2
- Document ID: US12593863B2
- Status: Granted
- Kind: B2
- Application number: 18/248,077
- Filed: 2021-10-08
- Published: 2023-11-30
- Granted: 2026-04-07
- Earliest claimed: 2020-10-09
- Assignees: International N&H Denmark Aps
- Applicants: Dupont Nutrition Biosciences Aps
- Inventors: Sile Griffin; Elaine Patterson; Markus Lehtinen
- Web page: https://patentgrep.com/patent/US12593863B2

## CPC

- A23L 33/135: Bacteria or derivatives thereof, e.g. probiotics
- A61K 35/747: Lactobacilli, e.g. L. acidophilus or L. brevis
- A61K 35/744: Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K 35/745: Bifidobacteria
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61K 2035/115: {Probiotics}
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

This invention relates to bacteria of the species Lacticaseibacillus paracasei for use in preventing or treating cognitive impairments in a subject in need thereof. This invention also relates to bacteria of the species Lacticaseibacillus paracasei for use in preventing or treating cognitive impairments induced by sleep deprivation and/or insufficient sleep in a subject in need thereof.

## Claims

### Claim 1

A method for treating cognitive impairments induced by sleep deprivation or insufficient sleep or both in a subject in need thereof, wherein the sleep deprivation or the insufficient sleep or both are due to a sleep disorder, comprising:
administering to the subject an effective amount of a combination of DGCC4981 (Lpc-37), registered at the DSMZ under deposit number DSM3261 on Oct. 5, 2017 of the species Lacticaseibacillus paracasei, Lactiplantibacilllus plantarum strain Lp-115,
and Bifidobacterium animalis ssp. lactis DGCC420 (B420) registered at the DSMZ under deposit number DSM32073 on Jun. 30, 2015.

### Claim 2 (depends on 1)

The method according to claim 1, wherein the sleep disorder is selected from one or more of sleep apnea, narcolepsy, insomnia and parasomnia.

### Claim 3 (depends on 1)

The method according to claim 1, wherein the combination is administered to the subject as part of a food product, a food ingredient, a dietary supplement or a pharmaceutical composition.

### Claim 4 (depends on 1)

The method according to claim 1, wherein the effective amount is 1.5×109 Colony-Forming Units of the combination per dose.

### Claim 5 (depends on 1)

The method according to claim 1, wherein the effective amount ranges from 106 Colony-Forming Units to 1012 Colony-Forming Units of the combination per dose.