US 12,591,781 B2 · Methods and systems for determining optimal decision time related to embryonic implantation

Abstract

Methods and systems are for improvements to in-vitro fertilization using morpho-kinetic signatures. These improvements are achieved by analyzing a series of images of a developing embryo (e.g., time-lapse images) as opposed to a single static image. For example, due to the difficulty in identifying clear distinctions between morphological states based on static images, as well as the unpredictability of morpho-kinetic development of an embryo, the system analyzes the development of an embryo as a whole over a given time frame (e.g., fertilization to blastulation), which provides a better prediction of the viability of a given embryo. The analysis may take the form of a morpho-kinetic signature, which itself may be used to determine an optimal time to transfer and/or implant an embryo into a patient.

Claims26

Dependent claims

A method of determining an optimal decision time related to embryonic implantation, the method comprising:

receiving, using control circuitry, a first morpho-kinetic signature of a first embryo, wherein the first morpho-kinetic signature is a representation of morpho-kinetic events in the first embryo as a function of time;
labeling, using the control circuitry, the first morpho-kinetic signature with a known time of peak implantation;
training, using the control circuitry, an artificial neural network to detect the known time of peak implantation based on the first morpho-kinetic signature;
receiving, using the control circuitry, a second morpho-kinetic signature of a second embryo with an unknown time of peak implantation, wherein the second morpho-kinetic signature is a representation of morpho-kinetic events in the second embryo as a function of time;
inputting, using the control circuitry, the second morpho-kinetic signature into the trained artificial neural network;
and
receiving, using the control circuitry, a prediction from the trained artificial neural network that the second morpho-kinetic signature corresponds to the known time of peak implantation.

4 more elements

A non-transitory computer-readable media comprising instructions that, when executed by one or more processors, cause operations comprising:

receiving a first morpho-kinetic signature of a first embryo, wherein the first morpho-kinetic signature is a representation of morpho-kinetic events in the first embryo as a function of time;
labeling the first morpho-kinetic signature with a known time of peak implantation;
training an artificial neural network to detect the known time of peak implantation based on the first morpho-kinetic signature;
receiving a second morpho-kinetic signature of a second embryo with an unknown time of peak implantation, wherein the second morpho-kinetic signature is a representation of morpho-kinetic events in the second embryo as a function of time;
inputting the second morpho-kinetic signature into the trained artificial neural network;
and
receiving a prediction from the trained artificial neural network that the second morpho-kinetic signature corresponds to the known time of peak implantation.

4 more elements

Dependencies are inferred from the claim text.

Methods and systems for determining optimal decision time related to embryonic implantation

Life of this patent

Methods and systems for determining optimal decision time related to embryonic implantation

Life of this patent

Abstract

Claims26