Method for measuring platelet activation based on soluble CLEC-2 and platelet count

A method for grasping a status of platelet activation, comprising:

• obtaining or having obtained one or more samples from a human subject, wherein the one or more samples are plasma and/or whole blood;
• measuring a concentration of soluble CLEC-2 and a platelet count in the one or more samples, wherein the platelet count is measured from a whole blood sample and the concentration of soluble CLEC-2 is measured from a plasma sample or the whole blood sample;
• calculating a ratio of the concentration of soluble CLEC-2 to the platelet count in the one or more samples to identify the human subject as having or at risk of having a thrombotic hemostatic disease;
• and
• administering a treatment to the human subject, wherein the treatment is an antiplatelet agent capable of treating the thrombotic hemostatic disease.