Methods and compositions for cardiovascular disease detection and management
AssigneeOhio State Innovation Foundation
InventorsSakima Smith, Craig Mcelroy, Patrick Dib
Life of this patent
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Abstract
Disclosed are compositions and methods for determining aberrant cardiac function or a predisposition to aberrant cardiac function, said method comprising detecting a fragment of βII spectrin associated with aberrant cardiac function or a predisposition to aberrant cardiac function in a sample derived from a subject, wherein the detection is indicative of aberrant cardiac function in the subject.
Claims15
A method for treating a subject with said aberrant cardiac function or predisposition to aberrant cardiac function accordingly, said method comprising a) detecting a fragment or fragments of βII spectrin associated with aberrant cardiac function or a predisposition to aberrant cardiac function in a sample derived from a subject, wherein the fragment or fragments comprise SBP50,60,75, wherein the detection is indicative of aberrant cardiac function in the subject;
- and b) monitoring the subject for aberrant cardiac function with an echocardiogram, stress-testing and/or an angiogram.
Dependencies are inferred from the claim text.