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US 12,590,966 B2Granted
Method for treating cancer
AssigneeChildren's Medical Center Corporation
InventorsAlejandro Gutierrez, Laura Hinze
Life of this patent
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Abstract
Described herein are methods and compositions for treating cancer. Aspects of the invention relate to determining if a biological sample obtained from a subject for GSK3α bodies (puncta), e.g., in response to asparaginase treatment, and administering to a subject having cancer an asparaginase and an agent that inhibits GSK3α to a subject who has been identified as forming GSK3α-positive bodies.
Claims17
A method of treating cancer, the method comprising:
- a) obtaining a biological sample from a subject having cancer;
- b) assaying the sample and identifying the cancer as forming GSK3α-positive puncta;
- and
- c) administering an asparaginase and an agent that inhibits GSK3α to the subject who has been identified as forming GSK3α-positive puncta,
- wherein the assaying is treating the sample with an the asparaginase, or culturing the sample in conditions of asparagine starvation or amino acid starvation.
2 more elements
Dependencies are inferred from the claim text.