Methods and compositions for treating inflammatory conditions associated with infectious disease
AssigneeDirect Biologics, LLC
InventorsKenneth Allen Pettine, Kevin Hicok, Timothy Alexander Moseley
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Abstract
Disclosed are methods of treating perianal fistula a subject by administering a therapeutic MSC secretome product made by a method comprising culturing bone marrow-derived MSCs under conditions that include oxygen tension below 5% and a culture media with a pH below 7.
Claims18
A method of treating acute respiratory distress syndrome (ARDS) in a subject in need thereof, the method comprising administering to the subject a composition comprising a therapeutically effective amount of a bone marrow mesenchymal stem cell (MSC) secretome that comprises stem cell factor 1 (SCF1), ferritin protein, tissue inhibitor of metalloproteinases 1 (TIMP1), and Insulin-like growth factor binding protein-4 (IGFBP-4), wherein the treating comprises reducing inflammation in the subject as demonstrated by a reduction in C-reactive protein (CRP), ferritin, and D-dimer.
Dependencies are inferred from the claim text.