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AssigneeInhibrx Biosciences, Inc.
InventorsJohn C. Timmer, Michael D. Kaplan, Katelyn M. Willis, Rajay A. Pandit, Angelica N. Sanabria, Sydney A. Barnes, Margaret E. Haerr, Brendan P. Eckelman, Rutger H. Jackson
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Provided herein are binding polypeptides that specifically bind 5T4. More specifically, provided herein are fusion proteins, including multivalent and/or multispecific constructs and chimeric antigen receptors, that bind 5T4. Also provided are pharmaceutical compositions containing the polypeptides, nucleic acid molecules encoding the polypeptides and vectors and cells thereof, and methods of use and uses of the provided 5T4 binding polypeptides for treating diseases and conditions, such as cancer.
A 5T4-binding polypeptide construct, comprising at least one heavy chain only variable domain (5T4 VHH domain) comprising a complementarity determining region 1 (CDR1) comprising the amino acid sequence selected from the group consisting of SEQ ID NO:
An isolated single domain antibody (sdAb) that binds 5T4, comprising a complementarity determining region 1 (CDR1) comprising the amino acid sequence selected from the group consisting of SEQ ID NO:
Dependencies are inferred from the claim text.