US 12,590,161 B2 · Anti-C-MPL antibody and use thereof

Abstract

The present invention relates to a novel anti-C-MPL antibody and a use thereof, and specifically, to an anti-C-MPL antibody having an effect of increasing platelet production and its number through the maturation of megakaryocytes in the bone marrow, and a use thereof. The novel anti-C-MPL antibody (2R13) of the present invention is a polymer material and has a longer half-life than the conventional therapeutic agents, and it has the advantage of low self-antibody production and low immunogenicity as an antibody agent. In addition, it can be used as a therapeutic agent for thrombocytopenia by increasing the platelet level of patients suffering from chronic or complication-induced immune thrombocytopenia.

Claims4

Dependent claims

An anti-c-MPL antibody or antigen-binding fragment thereof, comprising:

a heavy chain variable region comprising a heavy chain CDR1 composed of amino acid sequence SEQ ID NO:
1, a heavy chain CDR2 composed of amino acid sequence SEQ ID NO:
2, and a heavy chain CDR3 composed of amino acid sequence SEQ ID NO:
3;
and
a light chain variable region comprising a light chain CDR1 composed of amino acid sequence SEQ ID NO:
4, a light chain CDR2 composed of amino acid sequence SEQ ID NO:
5, and a light chain CDR3 composed of amino acid sequence SEQ ID NO:
6.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/038,497Filed 9 Nov 2021

Priority

KR 10-2020-015849924 Nov 2020

Published

US 2024/0010736 A111 Jan 2024

Granted

31 Mar 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07K 16/2866
Against receptors, cell surface antigens or cell surface determinants: against receptors for cytokines, lymphokines, interferons
A61K 39/00
Medicinal preparations containing antigens or antibodies
A61P 7/06
Drugs for disorders of the blood or the extracellular fluid: antianaemics
A61K 2039/505
Medicinal preparations containing antigens or antibodies: comprising antibodies

Anti-C-MPL antibody and use thereof

Life of this patent

Anti-C-MPL antibody and use thereof

Life of this patent

Abstract

Claims4