Molecules binding PD-L1 and uses thereof
AssigneeBeijing Mabworks Biotech Co., Ltd.
InventorsXuechen Zhou, Guangzhong Lin, Jiangmei Li, Wenqi Hu, Feng Li
Life of this patent
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Abstract
Disclosed is a molecule, e.g., a single-domain antibody, or a heavy chain only antibody, that specifically binds human PD-L1, and its use in treating diseases such as tumors.
Claims17
An isolated molecule, which binds PD-L1, comprising a heavy chain variable region, wherein the heavy chain variable region comprises a CDR1, a CDR2 and a CDR3 respectively comprising the amino acid sequences of (1) SEQ ID NOs:
- 1, 2 (X1=T, B=N, X2=A) and 3 (X=K);
- or (2) SEQ ID NOs:
- 1, 2 (X1=L, B=D, X2=V) and 3 (X=A).
An isolated molecule, which binds PD-L1, comprising a heavy chain variable region, wherein the heavy chain variable region comprises a CDR1, a CDR2 and a CDR3 from a heavy chain variable region comprising the amino acid sequences of SEQ ID NOs:
- 4, 5, 6, 7, 8 or 9.
Dependencies are inferred from the claim text.