Antibody and bispecific antibody targeting LAG-3 and use thereof
AssigneeL&L Bio Co., Ltd., Ningbo, China
InventorJiajian Liu
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Abstract
Disclosed is a LAG-3 binding protein, comprising a light chain variable region and/or a heavy chain variable region. The light chain variable region comprises a CDR1 having an amino acid sequence as shown in SEQ ID NO: 5, a CDR2 having an amino acid sequence as shown in SEQ ID NO: 6, and/or a CDR3 having an amino acid sequence as shown in SEQ ID NO: 7. The heavy chain variable region comprises a CDRI having an amino acid sequence as shown in SEQ ID NO: 8, a CDR2 having an amino acid sequence as shown in SEQ ID NO: 9, and/or a CDR3 having an amino acid sequence as shown in SEQ ID NO: 10. Also disclosed are a bispecific antibody targeting LAG-3 and use thereof. The LAG-3 binding protein and bispecific antibody above can effectively block the binding of LAG-3 to MHC II and activate T cells.
Claims20
A lymphocyte-activation gene 3 (LAG-3) binding protein comprising a light chain variable region and a heavy chain variable region;
- wherein the light chain variable region comprises a CDR1 having an amino acid sequence of SEQ ID NO:
- 5, a CDR2 having an amino acid sequence of SEQ ID NO:
- 6, and a CDR3 having an amino acid sequence of SEQ ID NO:
- 7;
- the heavy chain variable region comprises a CDR1 having an amino acid sequence of SEQ ID NO:
- 8, a CDR2 having an amino acid sequence of SEQ ID NO:
- 9, and a CDR3 having an amino acid sequence of SEQ ID NO:
- 10.
Dependencies are inferred from the claim text.