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US 12,590,147 B2Granted
TRPV1 epitopes and antibodies
AssigneeOblique Therapeutics AB
InventorsCarolina Trkulja, Max Davidson, Owe Orwar
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Abstract
The present invention relates to antibodies that bind to TRPV1. The invention also relates to certain epitopes of the protein TRPV1. The invention also relates to immunoconjugates and compositions comprising such antibodies. The invention also provides methods of producing such antibodies. The invention further provides the use of such antibodies for therapeutic purposes, for example in the treatment of pain.
Claims10
An antibody which binds to TRPV1, wherein said antibody binds
- to TRPV1 in the extracellular region of TRPV1 wherein the antibody comprises a heavy chain variable region comprising three complementarity determining regions (CDRs) and a light chain variable region comprising three CDRs, wherein the heavy chain variable region comprises a variable heavy (VH) CDR1 comprising the amino acid sequence of SEQ ID NO:
- 363, a VH CDR2 comprising the amino acid sequence of SEQ ID NO:
- 364, and a VH CDR3 comprising the amino acid sequence of SEQ ID NO:
- 365, and wherein the light chain variable region comprises a variable light (VL) CDR1 comprising the amino acid sequence of SEQ ID NO:
- 366, a VL CDR2 comprising the amino acid sequence of SEQ ID NO:
- 367, and a VL CDR3 comprising the amino acid sequence of SEQ ID NO:
- 368.
4 more elements
Dependencies are inferred from the claim text.