CLDN18.2-targeting antibody, preparation method therefor, and use thereof
AssigneeNona Biosciences (Suzhou) Co., Ltd.
InventorsMing-Jin Jheng, Wei Zhang, Jieli Wang
Life of this patent
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Abstract
Provided are a CLDN18.2-targeting antibody or an antigen-binding fragment thereof, a preparation method therefor, and the use thereof. The antibody comprises a light chain variable region and/or a heavy chain variable region, and the heavy chain variable region comprises HCDR1, HCDR2 and HCDR3, and the light chain variable region comprises LCDR1, LCDR2 and LCDR3. Compared with the prior art, the antibody has significant advantages in terms of binding affinity, ADCC, CDC, inhibitory effects on growth, endocytic activity, etc.
Claims19
An antibody targeting CLDN18.2 or an antigen-binding fragment thereof, comprising a light chain variable region and a heavy chain variable region, the heavy chain variable region comprises HCDR1, HCDR2 and HCDR3, the light chain variable region comprises LCDR1, LCDR2 and LCDR3;
- wherein,
- amino acid sequence of the HCDR1 is SEQ ID NO:
- 7, amino acid sequence of the HCDR2 is SEQ ID NO:
- 17, amino acid sequence of the HCDR3 is SEQ ID NO:
- 27, and amino acid sequence of the LCDR1 is SEQ ID NO:
- 41, amino acid sequence of the LCDR2 is SEQ ID NO:
- 48, and amino acid sequence of the LCDR3 is SEQ ID NO:
- 56;
- or,
- amino acid sequence of the HCDR1 is SEQ ID NO:
- 8, amino acid sequence of the HCDR2 is SEQ ID NO:
- 18, amino acid sequence of the HCDR3 is SEQ ID NO:
- 28, and amino acid sequence of the LCDR1 is SEQ ID NO:
- 42, amino acid sequence of the LCDR2 is SEQ ID NO:
- 47, and amino acid sequence of the LCDR3 is SEQ ID NO:
- 57;
- or,
- amino acid sequence of the HCDR1 is SEQ ID NO:
- 8, amino acid sequence of the HCDR2 is SEQ ID NO:
- 16, amino acid sequence of the HCDR3 is SEQ ID NO:
- 29, and amino acid sequence of the LCDR1 is SEQ ID NO:
- 42, amino acid sequence of the LCDR2 is SEQ ID NO:
- 47, and amino acid sequence of the LCDR3 is SEQ ID NO:
- 55;
- or,
- amino acid sequence of the HCDR1 is SEQ ID NO:
- 8, amino acid sequence of the HCDR2 is SEQ ID NO:
- 16, amino acid sequence of the HCDR3 is SEQ ID NO:
- 29, and amino acid sequence of the LCDR1 is SEQ ID NO:
- 42, amino acid sequence of the LCDR2 is SEQ ID NO:
- 47, and amino acid sequence of the LCDR3 is SEQ ID NO:
- 58;
- or,
- amino acid sequence of the HCDR1 is SEQ ID NO:
- 8, amino acid sequence of the HCDR2 is SEQ ID NO:
- 19, amino acid sequence of the HCDR3 is SEQ ID NO:
- 28, amino acid sequence of the LCDR1 is SEQ ID NO:
- 42, amino acid sequence of the LCDR2 is SEQ ID NO:
- 47, and amino acid sequence of the LCDR3 is SEQ ID NO:
- 57.
Dependencies are inferred from the claim text.