US 12,590,141 B2Granted

Monoclonal antibodies against Henipavirus glycoprotein G and encoding nucleic acids thereof

AssigneeAcademy of Military Medical Science, PLA

InventorsWei Chen, Changming Yu, Yujiao Liu, Pengfei Fan, Guanying Zhang, Yaohui Li, Jianmin Li, Xiangyang Chi, Meng Hao, Ting Fang, Yunzhu Dong, Xiaohong Song, Yi Chen, Shuling Liu

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Abstract

Provided is an anti-Henipavirus monoclonal antibody having broad spectrum neutralization activity, wherein the antibody comprises a macaque variable region and a human constant region. The antibody of the present invention has good binding activity to both Nipah virus glycoprotein G and Hendra virus glycoprotein G, can effectively neutralize Nipahpseudovirus and Hendra pseudovirus, and can be used for preparing drugs for treating Henipavirus diseases.

Claims9

Dependent claims

A monoclonal antibody against Henipavirus glycoprotein G, wherein the amino acid sequence of the CDR1, CDR2, and CDR3, of the heavy chain variable region of the said antibody and the amino acid sequence of the CDR1, CDR2, and CDR3 of the light chain variable region of the said antibody are respectively shown as the following sequence combinations:

26-33, 51-58, 97-116 of SEQ ID NO:1 and 27-36, 54-56, 93-100 of SEQ ID NO:3, or
26-33, 51-58, 97-117 of SEQ ID NO:5 and 27-32, 50-52, 89-97 of SEQ ID NO:7, or
26-33, 51-58, 97-115 of SEQ ID NO:9 and 27-32, 50-52, 89-97 of SEQ ID NO:
11, or
26-33, 51-58, 97-109 of SEQ ID NO:13 and 27-37, 51-53, 90-100 of SEQ ID NO:15.

2 more elements

Dependencies are inferred from the claim text.