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US 12,590,137 B2Granted
Meditope-enabled T cells
AssigneeCity of Hope
InventorsJohn C. Williams, Christine Brown, Kurt Jenkins, Yi-Chiu Kuo, Cheng-Fu Kuo
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Abstract
Provided herein are compositions which exhibit novel therapeutic capabilities and allow to reduce the off-target effect of therapeutic antibodies. The compositions include recombinant proteins that if expressed by a T cell can efficiently recruit therapeutic antibodies to their site of action.
Claims18
A recombinant protein comprising:
- (i) a meditope capable of binding a meditope-enabled Fab;
- (ii) an intracellular T-cell signaling domain;
- and
- (iii) a transmembrane domain connecting said meditope to said intracellular T-cell signaling domain;
- wherein said recombinant protein does not comprise an antigen binding domain.
2 more elements
Dependencies are inferred from the claim text.