Stabilized extracellular domain of CD19
AssigneeUniversitäT FüR Bodenkultur Wien
InventorsElisabeth Laurent, Michael Traxlmayr, Renate Kunert
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Abstract
An extracellular domain of CD19 (CD19-ECD) which comprises at least 90% sequence identity to SEQ ID NO:1, a first core region at positions 2-98 of SEQ ID NO:1, a second core region at positions 167-258 of SEQ ID NO:1, a third core region at positions 99-166 of SEQ ID NO:1, and at least one stabilizing point mutation at an amino acid position within said first and/or second and/or third core regions, wherein the CD19-ECD has an increased thermal stability compared to CD19-ECD which consists of an amino acid sequence identified as SEO ID NO:1.
Claims13
An isolated extracellular domain of CD19 (CD19-ECD) which comprises a first core region at positions 2-98 of SEQ ID NO:1, a second core region at positions 167-258 of SEQ ID NO:1, and a third core region at positions 99-166 of SEQ ID NO:1, wherein the first core region comprises a point mutation selected from the group consisting of M56V, R57S and F66S, and wherein the CD19-ECD has an increased thermal stability compared to CD19-ECD which consists of an amino acid sequence identified as SEQ ID NO:1.
Dependencies are inferred from the claim text.