Bipartite molecules and uses thereof in treating diseases associated with abnormal protein aggregates
AssigneeAcademia Sinica
InventorsBenjamin Pang-Hsien Tu, Rita Py Chen, Joseph Jen-Tse Huang, Yijuang Chern, Yu-Song Jang, Xiang-Me Lai, Tai-Yan Liao, Te-Hsien Kung
Life of this patent
Estimating the term…
Abstract
Bipartite molecules comprising a peptide affinity moiety and at least one charged moiety and uses thereof in reducing formation of abnormal protein aggregate and treating diseases associated with such abnormal protein aggregate, including neurodegenerative disease characterized by formation of protein aggregates.
Claims6
A method for treating Alzheimer's disease (AD), comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition, wherein the pharmaceutical composition comprises a bipartite molecule and a pharmaceutically acceptable carrier, and the bipartite molecule is
- (a) a molecule comprising the amino acid sequences of RRRRRRRRGSNKGAHGLM-PEI (SEQ ID NO:
- 4), wherein the C-terminal PEI is polyethylenimine;
- or
- (b) a molecule comprising the amino acid sequences of YEVHHOKLYFFAEDDPGSNKGANGLMYGGVV-PEI (SEQ ID NO:
- 5), wherein the C-terminal PEI is polyethylenimine.
A method for treating Huntington's disease (HD), comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition, wherein the pharmaceutical composition comprises a bipartite molecule and a pharmaceutically acceptable carrier, and the bipartite molecule is
- (a) a molecule comprising the amino acid sequences of RRRRRRRRWDQQQQQQQQQQ (SEO ID NO:
- 6);
- or
- (b) a molecule comprising the amino acid sequences of RRRRRRRRWDQQQQQQQQQQQQQQQ (SEO ID NO:
- 7).
Dependencies are inferred from the claim text.