Peptide inhibitors for the inhibition of HIV capsid
AssigneeThe Curators of the University of Missouri
InventorsUjjwal Neogi, Anders Sonnerborg, Kamlendra Singh, Thomas P. Quinn, Fabio Gallazzi
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Abstract
Provide for herein are cyclic or linear peptides that bind HIV-1 capsid protein and inhibit HIV-1 capsid from assembling and/or disassembling. Further provided are methods of making said peptides and pharmaceutical compositions and methods for treating HIV infection.
Claims25
A cyclic peptide comprising the amino acid sequence of F-X1-F-X2-P-V-X3-F (SEQ ID NO:
- 2), wherein X1, X2, and X3 are each independently glycine (G), lysine (K), or a polar uncharged amino acid.
A cyclic or linear peptide comprising an amino acid sequence of S-G-V-F-T-F-G-P-V-N-F-P-G (SEQ ID NO:
- 4) or S-G-V-F-Y-F-W-P-V-N-F-P-G (SEQ ID NO:
- 5), or a cyclic peptide comprising an amino acid sequence of S-G-V-F-T-F-G-P-V-N-F-P-G (SEQ ID NO:
- 4) or S-G-V-F-Y-F-W-P-V-N-F-P-G (SEQ ID NO:
- 5) except wherein the sequence has one or two amino acid substitutions.
A method of treating an HIV infection in a subject in need thereof, the method comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a cyclic peptide comprising an amino acid sequence of G-V-F-T-F-G-P-V-N-F-P-G (SEQ ID NO:
- 4) and a pharmaceutically acceptable carrier to the subject.
Dependencies are inferred from the claim text.