NRP-1 binding inhibitory peptides and uses thereof

A compound of formula (I) below:

• wherein,
• for groups R1 and R4,
• a) R1 is a group of formula
• and R4 is H, or
• b) R1 and R4, together with the carbon and nitrogen atoms to which they are linked, form a pyrrolidinyl ring, or
• c) R1 and R4, together with the carbon and nitrogen atoms to which they are linked, form a 2,5-dihydro-1-H-pyrrolyl ring, or
• d) R1 and R4, together with the carbon and nitrogen atoms to which they are linked, form a octahydro-1H-indolyl ring, or
• e) R1 is a group of formula
• and R4 is H,
• for groups R2 and R5,
• a) R2 is a group of formula
• and R5 is H, or
• b) R2 is a group of formula
• and R5 is H, or
• c) R2 and R5, together with the carbon and nitrogen atoms to which they are linked, form a pyrrolidinyl ring, or
• d) R2 and R5, together with the carbon and nitrogen atoms to which they are linked, form a 2,5-dihydro-1-H-pyrrolyl ring, or
• e) R2 and R5, together with the carbon and nitrogen atoms to which they are linked, form a octahydro-1H-indolyl ring, or
• f) R2 is a group of formula
• and R5 is H, or
• g) R2 is a group of formula
• and R5 is H,
• A is selected in the group of formulas A1 and A2 below:
• wherein A1 is of the formula:
• wherein X1 is selected in the group consisting of H, —C(═O)—CH3 and an amine protecting group, and
• wherein R3 is selected in the group consisting of
• a) R3 is a group of formula
• or
• b) R3 is a group of formula
• or
• c) R3 is a group of formula
• or
• d) R3 is a group of formula
• and wherein X2 is selected in the group consisting of H, —C(═O)—CH3 and an amine protecting group,
• and
• wherein A2 is of the formula below:
• wherein X3 and X4, which are identical or different, and are selected from the group consisting of H, —C(═O)—CH3 and an amine protecting group,
• provided that the compound of formula (I) does not consist of the peptide CKPPR or CTKPR,
• and pharmaceutically acceptable salts and/or racemic, enantiomeric, diastereoisomeric or tautomeric forms thereof.