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US 12,590,121 B2Granted
Peptide compound with repetitive sequences
OwnerCharlotte A.E. Hauser, Hepi Hari Susaptoinventors
Life of this patent
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Abstract
The present disclosure relates to ultrashort peptides capable of forming a gel, to a gel comprising a peptide in accordance with the present disclosure, and to a method of preparing such gel. Such gel is a hydrogel or an organogel. The peptides are suitable bioinks for a bioprinter to build 3D structures through 3D printing as well as other applications.
Claims56
An ultrashort peptide consisting of a sequence selected from the group consisting of:
- (SEQ ID NO:
- 2)
- IIFR
- (SEQ ID NO:
- 3)
- IIFD
- (SEQ ID NO:
- 4)
- IIFE
- (SEQ ID NO:
- 5)
- LLFK
- (SEQ ID NO:
- 6)
- LLFR
- (SEQ ID NO:
- 7)
- LLFD
- (SEQ ID NO:
- 8)
- LLFE
- (SEQ ID NO:
- 9)
- IIZK
- (SEQ ID NO:
- 10)
- IIZR
- (SEQ ID NO:
- 11)
- IIZD
- (SEQ ID NO:
- 12)
- IIZE
- (SEQ ID NO:
- 13)
- LLZK
- (SEQ ID NO:
- 14)
- LLZR
- (SEQ ID NO:
- 15)
- LLZD
- (SEQ ID NO:
- 16)
- LLZE
- (SEQ ID NO:
- 17)
- IFFK
- (SEQ ID NO:
- 18)
- IFFR
- (SEQ ID NO:
- 19)
- IFFD
- (SEQ ID NO:
- 20)
- IFFE
- (SEQ ID NO:
- 21)
- LFFK
- (SEQ ID NO:
- 22)
- LFFR
- (SEQ ID NO:
- 23)
- LFFD
- (SEQ ID NO:
- 24)
- LFFE
- (SEQ ID NO:
- 25)
- IZZK
- (SEQ ID NO:
- 26)
- IZZR
- (SEQ ID NO:
- 27)
- IZZD
- (SEQ ID NO:
- 28)
- IZZE
- (SEQ ID NO:
- 29)
- LZZK
- (SEQ ID NO:
- 30)
- LZZR
- (SEQ ID NO:
- 31)
- LZZD
- (SEQ ID NO:
- 32)
- LZZE
- (SEQ ID NO:
- 33)
- FFIK
- (SEQ ID NO:
- 34)
- ZZIR
- (SEQ ID NO:
- 35)
- FFID
- (SEQ ID NO:
- 36)
- FFIE
- (SEQ ID NO:
- 37)
- FFLK
- (SEQ ID NO:
- 38)
- FFLR
- (SEQ ID NO:
- 39)
- FFLD
- (SEQ ID NO:
- 40)
- FFLE
- (SEQ ID NO:
- 41)
- ZZIK
- (SEQ ID NO:
- 42)
- ZZIR
- (SEQ ID NO:
- 43)
- ZZID
- (SEQ ID NO:
- 44)
- ZZIE
- (SEQ ID NO:
- 45)
- ZZLK
- (SEQ ID NO:
- 46)
- ZZLR
- (SEQ ID NO:
- 47)
- ZZLD
- (SEQ ID NO:
- 48)
- ZZLE
- (SEQ ID NO:
- 49)
- FIIK
- (SEQ ID NO:
- 50)
- FIIR
- (SEQ ID NO:
- 51)
- FIID
- (SEQ ID NO:
- 52)
- FIIE
- (SEQ ID NO:
- 53)
- FLLK
- (SEQ ID NO:
- 55)
- FLLD
- (SEQ ID NO:
- 56)
- FLLE
- (SEQ ID NO:
- 57)
- ZIIK
- (SEQ ID NO:
- 58)
- ZIIR
- (SEQ ID NO:
- 59)
- ZIID
- (SEQ ID NO:
- 60)
- ZIIE
- (SEQ ID NO:
- 61)
- ZLLK
- (SEQ ID NO:
- 62)
- ZLLR
- (SEQ ID NO:
- 63)
- ZLLD
- (SEQ ID NO:
- 64)
- ZLLE
- (SEQ ID NO:
- 66)
- ZZZK,
- wherein I is isoleucine, L is leucine, F is phenylalanine, K is lysine, R is arginine, D is aspartic acid, E is glutamic acid, Z is cyclohexylalanine,
- wherein each of the sequences is connected to an acetylated or non-acetylated N-terminal protecting group, and may be amidated or non-amidated by a C-terminal protecting group,
- wherein the ultrashort peptide is capable of forming a gel by self-assembly,
- wherein the N-terminal protecting group is a peptidomimetic molecule,
- wherein the N-terminus of the peptidomimetic molecule may be modified with a functional group selected from the group consisting of:
- carboxylic acid, amide, alcohol, aldehyde, amine, imine, nitrile, an urea analog, phosphate, carbonate, sulfate, nitrate, maleimide, vinyl sulfone, azide, alkyne, alkene, carbohydrate, imide, peroxide, ester, aryl, ketone, sulphite, nitrite, phosphonate, and silane.
192 more elements
An ultrashort peptide sequences containing repetitive sequences, the peptide having a general formula selected from:
- AnBmX and XBmAn
- wherein the total number of amino acids of the ultrashort peptide does not exceed 7 amino acids;
- wherein A is an aliphatic amino acids, selected from the group consisting of:
- isoleucine, leucine or any combination thereof, with n being an integer being selected from 0-5;
- wherein B is comprised of at least one aromatic amino acid selected from the group consisting of:
- tyrosine, tryptophan, phenylalanine, hydrophobic amino acid phenylalanine, or comprised of a peptidomimetic amino acid that is the aliphatic counterpart of the aromatic amino acid;
- wherein X is comprised of a polar amino acid, selected from the group consisting of:
- aspartic acid, glutamic acid, lysine, arginine, histidine, cysteine, serine, threonine, asparagine, and glutamine.
5 more elements
Dependencies are inferred from the claim text.