Flavonoid derivative for treating dental caries
AssigneeMuhlbauer Technology GmbH
InventorsKaja Yorgan, Olav-Sven Becker
Life of this patent
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Abstract
The invention relates to a flavonoid derivative containing a flavonoid that is coupled to an alkylene group via an ether bond, said alkylene group having an adhesion group for adhesion onto a dental surface. The flavonoid derivative has a long-term suppressing effect on the dental disease-causing formation of biofilm on the dental surfaces treated with the flavonoid derivative. The invention further relates to a kit for producing such a flavonoid derivative, and to the use of same.
Claims15
A method for the prophylaxis and/or treatment of oral disease, comprising bonding a dental preparation to a tooth surface, wherein the dental preparation comprises at least one flavonoid derivative, wherein the at least one flavonoid derivative is a compound of formula (I):
- where
- i) R4=H, OH or an oxo group (═O);
- ii) R3, R5, R6, R7, R8, R21, R3I, R4I, R6I, R6I are each independently H, OH, OR1 where
- R1=methyl or acyl, rhamnose, glucose, oligoglucose, rutinose or Et-Q-Z where Et =O, i.e. O-Q-Z;
- iii) at least one of the radicals R3, R5, R6, R7, R8, R2I, R3I, R4I, R5I, R6I is Et-Q-Z where Et=O, i.e. O-Q-Z;
- iv) Q is a spacer group, wherein the spacer group Q is an alkylene group, which may optionally be interrupted by an oxygen atom, a nitrogen atom and/or a polyoxyalkylene group;
- and
- v) Z is an adhesion group, said Z group being selected from the group consisting of:
- —COOR2, —SO2OR2, —OPO(OR2)2, —PO(OR2)2, —CR1 (PO(OR2)2)2,
- with
- R1=H, OH or alkyl,
- R2=H, alkyl or M, where M is a monovalent cation.
A method for the prophylaxis and/or treatment of oral disease, comprising bonding a dental preparation to a tooth surface, wherein the dental preparation comprises at least one flavonoid derivative, wherein the at least one flavonoid derivative is a compound of formula (II):
- where
- i) R4=H, OH or an oxo group (═O);
- ii) R3, R5, R6, R7, R8, R2I, R3I, R4I, R5I, R6I are each independently H, OH, OR1 where R1=methyl or acyl, rhamnose, glucose, oligoglucose, rutinose or Et-Q-Z where Et =O, i.e. O-Q-Z;
- iii) at least one of the radicals R3, R5, R6, R7, R8, R2I, R3I, R4I, R5I, R6I is Et-Q-Z where Et=O, i.e. O-Q-Z;
- iv) Q is a spacer group, wherein the spacer group Q is an alkylene group, which may optionally be interrupted by an oxygen atom, a nitrogen atom and/or a polyoxyalkylene group;
- and
- v) Z is an adhesion group, said Z group being selected from the group consisting of:
- —COOR2, —SO2OR2, OPO(OR2)2, —PO(OR2)2, —CR1 (PO(OR2)2)2,
- with
- R1=H, OH or alkyl,
- R2=H, alkyl or M, where M is a monovalent cation.
A method for the prophylaxis and/or treatment of oral disease, comprising bonding a dental preparation to a tooth surface, wherein the dental preparation comprises at least one flavonoid derivative, wherein the at least one flavonoid derivative is a compound of formula (III):
- where
- i) R4=H, OH or an oxo group (═O);
- ii) R2, R5, R6, R7, R8, R2I, R3I, R4I, R5I, R6I are each independently H, OH, OR1 where
- R1=methyl or acyl, rhamnose, glucose, oligoglucose, rutinose or Et-Q-Z where Et =O, i.e. O-Q-Z;
- iii) at least one of the radicals R2, R5, R6, R7, R8, R2I, R3I, R4I, R5I, R6I is Et-Q-Z where Et=O, i.e. O-Q-Z;
- iv) Q is a spacer group, wherein the spacer group Q is an alkylene group, which may
- optionally be interrupted by an oxygen atom, a nitrogen atom and/or a
- polyoxyalkylene group;
- and
- v) Z is an adhesion group, said Z group being selected from the group consisting of:
- —COOR2, —SO2OR2, —OPO(OR2)2, —PO(OR2)2, —CR1 (PO(OR2)2)2,
- with
- R1=H, OH or alkyl,
- R2=H, alkyl or M, where M is a monovalent cation.
Dependencies are inferred from the claim text.