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US 12,590,110 B2Granted
Amorphous (a-polymorphic) psilocybin
AssigneeDiamond Therapeutics Inc.
InventorsJudith Blumstock, David Roger Brown, Christian Steup, Marc Zeplichal
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Abstract
Disclosed herein are compositions comprising amorphous psilocybin. The amorphous psilocybin may be a synthetic, a-polymorphic psilocybin. Also disclosed herein are methods of treatment using amorphous psilocybin and methods of manufacturing amorphous psilocybin.
Claims18
A method of making a synthetic, amorphous psilocybin, the method comprising:
- (a) providing a protected psilocybin;
- (b) deprotecting the protected psilocybin in a reaction solvent to provide psilocybin;
- (c) extracting the psilocybin from the reaction solvent into an aqueous medium and washing the aqueous medium with an organic solvent, wherein the psilocybin is purified by the extracting;
- (d) concentrating the aqueous medium comprising the psilocybin;
- and
- (e) collecting the amorphous psilocybin, wherein the collected amorphous psilocybin is at least 95% pure without the need for crystallization.
3 more elements
Dependencies are inferred from the claim text.