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US 12,590,108 B2Granted
Boracic acid compound
AssigneePhaeno Therapeutics Co., Ltd.
InventorDonghui Qin
Life of this patent
Estimating the term…
Abstract
A new class of boronic acid compounds. Specifically disclosed are compounds represented by Formula (II) or (II′), pharmaceutically acceptable salts thereof or stereoisomers thereof, and the application thereof in the preparation of a medicament for treating diseases associated with bacterial infection.
Claims17
A compound represented by Formula (II) or (II′) or a pharmaceutically acceptable salt thereof,
- wherein B is boron;
- T is —O—, —S—, or —Se—;
- each R1 is independently —OH or C1-3 alkoxy;
- R2 and R3 are each independently H or C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, Br, I, —OH, and —OCH3;
- R4 is H, F, Cl, Br, I, C1-3 alkyl, or C1-3 alkoxy, wherein the C1-3 alkyl and C1-3 alkoxy are each independently and optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, Br, I, −OH, and —OCH3;
- R5 is H, F, Cl, Br, I, or C1-3 alkoxy;
- R6 is H, F, Cl, Br, I, —ORa, or C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, Br, I, —OH, and —OCH3;
- or R5 and R6 together with the carbon atom to which they are attached form a 5-6-membered oxygen-containing non-aromatic heterocyclic ring, wherein the 5-6-membered oxygen-containing non-aromatic heterocyclic ring is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, Br, I, −OH, and —OCH3;
- R7 is H, C1-3 alkyl, —C(Rb)2OC(═O)Rc, or —C(Rb)2OC(═O)ORc, wherein the C1-3 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, Br, I, —OH, and —OCH3;
- Ra is H, C1-6 alkyl,
- wherein the C1-6 alkyl,
- are each independently and optionally substituted with 1, 2, or 3 Ra1;
- each Rb is independently H or C1-3 alkyl;
- Rc is H, C1-3 alkyl,
- wherein the C1-3 alkyl,
- are each independently and optionally substituted with 1, 2, or 3 Rc1;
- each Ra1 is independently F, Cl, Br, I, C1-3 alkyl, C1-3 alkoxy,
- wherein the C1-3 alkyl, C1-3 alkoxy,
- are each independently and optionally substituted with 1, 2, or 3 R;
- each Rc1 is independently F, Cl, Br, I, —OH, C1-3 alkyl, or C1-3 alkoxy;
- and
- each R is independently F, Cl, Br, I, —OH, or C1-3 alkyl, wherein the C1-3 alkyl is optionally substituted with 1, 2, or 3 substituents independently selected from F, Cl, Br, I, and
19 more elements
A compound of the following formula or a pharmaceutically acceptable salt thereof:
A compound of the following formula:
Dependencies are inferred from the claim text.