Polymorph of EP4 receptor antagonist, preparation method therefor and use thereof
AssigneeShanghai Yuyao Biotech Ltd.
InventorsHankun Zhang, Junjie Yang, Mingyao Liu, Wenbo Zhou, Shihong Peng, Huang Chen, Jian Lu
Life of this patent
Estimating the term…
Abstract
Provided are a polymorph of an EP4 receptor antagonist, a preparation method therefor and a use thereof, relating in particular to a polymorph of an EP4 receptor antagonist(S)-4-(1-(2-(4-fluorobenzyl)-4, 7-dihydro-5H-thieno [2,3-c]pyran-3-carboxamido) ethyl) benzoic acid, a preparation method therefor and a use thereof. Compared with an amorphous form of a compound represented by formula I, the polymorph of the present invention has higher stability and better processing performance and is very suitable for being prepared into a medicine.
Claims12
A polymorph of a compound of formula I, wherein the polymorph is polymorphic Form I, and the X-ray powder diffraction pattern of the polymorphic Form I has characteristic peaks at 2θ values of 4.234±0.2°, 8.505±0.2°, 8.96±0.2°, 11.177±0.2°, 12.892±0.2°, 18.05±0.2°, 23.333±0.2°,
A polymorph of a compound of formula I, wherein the polymorph is polymorphic Form II, and the X-ray powder diffraction pattern of the polymorphic Form II has characteristic peaks at 20 values of 4.018±0.2°, 8.722±0.2°, 9.382±0.2°, 11.539±0.2°, 17.732±0.2°, 18.038±0.2°, 19.13±0.2°,
A polymorph of a compound of formula I, wherein the polymorph is polymorphic Form IV, and the X-ray powder diffraction pattern of the polymorphic Form IV has characteristic peaks at 20 values of 8.529±0.2°, 9.177±0.2°, 9.696±0.2°, 11.324±0.2°, 17.556±0.2°, 17.824±0.2°, 28.107±0.2°,
Dependencies are inferred from the claim text.