US 12,590,100 B2 · Tetrahydro-spiroindoline-pyrrolopyrrole-triones inhibitors of the NRF2-β-TrCP interaction for use in the treatment of fatty liver disease

Tetrahydro-spiroindoline-pyrrolopyrrole-triones inhibitors of the NRF2-β-TrCP interaction for use in the treatment of fatty liver disease

OwnerAntonio Cuadrado Pastor, Raquel Fernandez Gines +6inventors

InventorsAntonio Cuadrado Pastor, Raquel Fernandez Gines, Jose Antonio Encinar, Rafael Leon Martinez, Juan Felipe Franco Gonzalez, Manuela Garcia Lopez, Maria Isabel Rodriguez Franco, Ana Isabel Rojo Sanchis

Life of this patent

Estimating the term…

Abstract

The present invention relates to NRF2-βTrCP interaction inhibitors with general formula I and its derivate salts for use in the treatment of NRF2-related diseases caused by chronic inflammation and oxidative stress. More specifically the present invention relates to NRF2-βTrCP interaction inhibitors with specific formula I and its derivate salts for treating diseases of the liver related with chronic inflammation and oxidative stress, such as fatty liver disease.

Claims3

Dependent claims

An NRF2-βTrCP interaction inhibitor, characterized by Formula (I) or its derivative salts,

wherein:
n can be 0 or 1,
R1 can be O2CCH3 or a six-membered ring for forming a benzodioxane, benzomethylenedioxy, or naphthalene substituent;
R2 can be H or a six-membered ring for forming a benzodioxane, benzomethylenedioxy, or naphthalene substituent;
R3 can be H or CH3;
R4 can be H or CH3;
and
R5 can be H, Cl, or CH3
for use in the treatment of fatty liver disease.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/027,990Filed 13 Jan 2022

Priority

EP 2138202515 Jan 2021

Published

US 2023/0348482 A12 Nov 2023

Granted

31 Mar 2026

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61K 31/404
Condensed with carbocyclic rings, e.g. carbazole: indoles, e.g. pindolol
C07D 487/20
In which the condensed system contains three hetero rings: spiro-condensed systems
A61K 31/407
Having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil: condensed with other…
A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…