Thyromimetics

A compound having the structure of Formula (I):

• or a tautomer, hydrate, solvate, isotope, or pharmaceutically acceptable salt thereof, wherein:
• A is;
• R6 is H or —CN;
• X1 is lower alkyl, lower alkenyl, lower haloalkyl, or halo,
• X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo;
• Y1 is H, —CN, halogen, lower alkyl, or lower alkoxy;
• Y2 is H, —CN, halogen, lower alkyl, or lower alkoxy;
• R2 is lower alkyl, lower alkenyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl, wherein R2 is optionally substituted with one or more halo, lower alkyl, lower haloalkyl, —CN, —OR′, —NR′R″, ═O, ═S, —S(O)2R′ or —S(O)2OR′;
• and
• R′ and R″ are each, independently, H, lower alkyl, or lower haloalkyl.