Back to results
US 12,590,070 B2Granted
Adamantane derivatives as inhibitors of focal adhesion kinase
AssigneesSamjin Pharmaceutical Co., Ltd., Incheon National University Research & Business Foundation, Bamichem Co., Ltd
InventorsMin Hyo Ki, Ho Seok Kwon, Young Hun Lee, Eunsun Song, Yong Bin Park, Kug Hwa Lee, Hyoung Min Cho, Soon Kil Ahn, Sung Pyo Hong, Sung Hye Kim
Life of this patent
Estimating the term…
Abstract
The present invention provides novel adamantane derivatives as inhibitors of a focal adhesion kinase, pharmaceutically acceptable salts thereof, stereoisomers thereof, hydrates or solvates thereof, and a pharmaceutical composition comprising same.
Claims17
An adamantane derivative represented by formula 1 below, a pharmaceutically acceptable salt thereof, stereoisomer thereof, hydrate or solvate thereof:
- wherein in above formula 1,
- L1 and L2 are each independently a single bond, C1-10 alkylene, C2-10 alkenylene, C2-10 alkynylene, —N(Ra)—, —C(═O)—N(Ra)—, —N(Ra)—C(═O)—, —C(═O)—, —O—, —C(═O)—O—, —N(Ra)— C(═O)—O—, —N(Ra)—S(═O)—, —N(Ra)—S(═O)2—, —S(═O)(═N—Ra)—, or —S—;
- R1 and R2 are each independently C1-10 heterocycloalkylene, C3-10 cycloalkylene, C5-16 arylene or C4-10 heteroarylene;
- R3 is H, C1-10 alkyl, C2-10 alkenyl, —O—Ra, ═O, —NH—Ra, —NH(C═O)—Ra or C1-10 heterocycloalkyl;
- R4 is —O—Ra;
- R5 and R6 are each independently H or C1-10 alkyl;
- R7 is —CF3 or a halogen atom;
- Ra is H, —CF3 or C1-10 alkyl;
- and
- m, n, p and q are each independently 0 or 1.
7 more elements
Dependencies are inferred from the claim text.