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US 12,590,068 B2Granted
Crystalline salts of a plasma kallikrein inhibitor
AssigneeBioCryst Pharmaceuticals, Inc.
InventorsYahya El-Kattan, Yarlagadda S. Babu
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Abstract
Disclosed are crystalline salts of Compound I, methods of preparing them, and related pharmaceutical preparations thereof. Also disclosed are methods of treatment using the crystalline salts of the invention.
Claims30
A crystalline salt of compound I,
- wherein the crystalline salt is a bis(hydrochloride) salt and contains less than 10% of the corresponding amorphous compound.
A pharmaceutical composition comprising a crystalline salt of compound I,
- and one or more pharmaceutically acceptable carriers, wherein said composition is for oral administration, and wherein the crystalline salt that is formulated with the one or more pharmaceutically acceptable carriers is a bis(hydrochloride) salt that contains less than 10% of the corresponding amorphous compound.
Dependencies are inferred from the claim text.